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. Author manuscript; available in PMC: 2013 Dec 16.
Published in final edited form as: Chemistry. 2012 Oct 23;18(51):10.1002/chem.201202085. doi: 10.1002/chem.201202085

Scheme 5.

Scheme 5

Scope and Evaluation of Alkynylation with Reduced Stoichiometry.

[a] 10 mol % (S,S)-1 used in reaction. [b] 20 mol % (S,S)-1, 40 mol % TPPO used in conjunction with a 24 h premix. [c] 20 mol % (S,S)-1 used in reaction. [d] 20 mol % TPPO used in this reaction. [e] 3.0 Equiv of Me2Zn used in reaction. [f] Reaction performed with (R,R)-1.