Comparison between the location of tender points and BAT depots in humans. Panel A shows the location of the 18 tender points, located symmetrically, used to characterize the pain of fibromyalgia (http://www.niams.nih.gov/Health_Info/Fibromyalgia/default.asp). Panel B shows the PET scan of an individual taken during exposure to cold (left panel of figure 1B), when BAT tissue is active and visible, compared to when exposed to thermoneutral conditions (right panel of figure 1B) (from Lichtenbelt, Vanhommerig, Smulders, Drossaerts, Kemerink, Bouvy, Schrauwen and Teule).89