Different histologic features of lung cancer in never smokers. Histologic distribution of lung cancers in never smokers compared with smokers. Cases of bronchioloalveolar carcinoma included with adenocarcinoma. Histologic subtypes were classified as adenocarcinoma, squamous cell carcinoma, or others. Ratio of the number of adenocarcinoma to squamous cell carcinoma was 0.4:1 in smokers, whereas it was 3.4:1 in never smokers. (Adapted from Sun S, Schiller JH, Gazdar AF. Lung cancer in never smokers—a different disease. Nat Rev Cancer 2007;7(10):778–90; with permission.)