Table 2.

SNP-SNP Interaction Analysis

Gene	SNP	Combined Dataset								ADNI-1 Dataset		ADNI2/GO Dataset
		MAF	a T	b R2	p-value	c FWE	d FDR	eχ2	p-value	Ta	p-value	Ta	p-value
APPB2 x GSK3β	rs2585590 x rs334543	0.46	4.41	0.015	1.2 × 10−5	0.052	0.036	11.14	1.0 × 10−3	3.21	0.002	3.17	0.002
		0.31
APPB2 x GSK3β	rs3098914 x rs334543	0.24	−4.25	0.012	2.5 × 10−5	0.107	0.036	10.63	1.0 × 10−3	−2.51	0.013	−3.37	0.001
		0.31
APP x GSK3β	rs457581 x rs334543	0.25	4.25	0.015	2.5 × 10−5	0.107	0.036	13.86	2.0 × 10−4	1.85	0.066	3.51	0.001
		0.31

^aT value for SNP x SNP interaction term

^bR² value represents the change in R² when introducing the SNP x SNP interaction term into the post-hoc hierarchical linear regression model.

^cFWE represents the p-value when correcting for multiple comparisons using the Bonferroni procedure (4,175 tests)

^dFDR represents the p-value when correcting for multiple comparisons using the false discovery rate procedure

^eχ² value for SNP x SNP interaction term in the post-hoc binary logistic regression model using amyloid positive/negative status as outcome