Table 2.

Odds Ratios for the Association Between DM and Risk of Colorectal Adenomas in a Matched Case-Control Study^a Nested in the Black Women's Health Study, 1997–2009

DM Status by Adenoma Type	No. of Cases	No. of Controls	Age-adjusted ORb	95% CI	Multivariable- adjustedc ORb	95% CI
Colorectal adenoma
No DM	804	2,378	1.00	Referent	1.00	Referent
DM	113	373	0.89	0.71, 1.12	0.83	0.64, 1.09
DM without insulin use	81	306	0.78	0.60, 1.01	0.75	0.56, 1.00
DM with insulin use	32	67	1.41	0.92, 2.17	1.23	0.75, 2.02
Colon adenoma
No DM	734	2,160	1.00	Referent	1.00	Referent
DM	99	339	0.86	0.67, 1.09	0.80	0.60, 1.05
DM without insulin use	71	279	0.75	0.57, 0.99	0.71	0.52, 0.97
DM with insulin use	28	60	1.37	0.86, 2.17	1.21	0.71, 2.07
Distal adenoma
No DM	318	940	1.00	Referent	1.00	Referent
DM	41	137	0.88	0.60, 1.29	0.81	0.52, 1.28
DM without insulin use	30	110	0.80	0.52, 1.23	0.76	0.46, 1.24
DM with insulin use	11	27	1.20	0.58, 2.45	1.07	0.45, 2.58
Proximal adenoma
No DM	480	1,417	1.00	Referent	1.00	Referent
DM	72	239	0.89	0.67, 1.18	0.83	0.60, 1.14
DM without insulin use	52	198	0.78	0.56, 1.07	0.72	0.50, 1.04
DM with insulin use	20	41	1.45	0.83, 2.53	1.38	0.74, 2.59
Rectal adenoma
No DM	80	237	1.00	Referent	1.00	Referent
DM	12	39	0.91	0.45, 1.84	0.99	0.41, 2.35
DM without insulin use	11	31	1.06	0.50, 2.24	1.40	0.56, 3.52
DM with insulin use	1	8	0.38	0.05, 3.02	0.11	0.01, 1.48

Abbreviations: CI, confidence interval; DM, diabetes mellitus; OR, odds ratio.

^a Cases and controls were matched on age and follow-up time.

^b Based on a conditional logistic regression model.

^c Adjusted for age, educational status, body mass index (weight (kg)/height (m)²), physical activity, family history of colorectal cancer in a first-degree relative, menopausal status, smoking status, alcohol intake, total energy intake, red meat intake, fruit and vegetable intake, and regular aspirin use.