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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Transl Stroke Res. 2013 Aug 17;4(6):10.1007/s12975-013-0280-3. doi: 10.1007/s12975-013-0280-3

Fig. 1.

Fig. 1

Chaperone machinery regulates ER-mitochondria Ca2+ crosstalk at the MAM. Both GRP75 and GRP78 are directly associated with MAM in the control of Ca2+ signaling between ER and mitochondria and HSP72 might regulate MAM indirectly through BCL2 which is directly associated with MAM. Cyt c: cytochrome c; IP3R: inositol trisphosphate receptor; MCU: mitochondrial Ca2+ uniporter; SIG1R: sigma-1 receptor; VDAC: voltage-dependent anion channel.