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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Transl Stroke Res. 2013 Aug 17;4(6):10.1007/s12975-013-0280-3. doi: 10.1007/s12975-013-0280-3

Fig. 4.

Fig. 4

miRNA control of chaperone networks. Ischemia leads to mitochondrial Ca2+ overload through MAM and then dysfunction of mitochondria releases ROS, a key element linking the organelle network to the inflammatory network of chaperone. One miRNA (miR-200 or miR-181) or its antagomir/inhibitor can target HSP70/GRP75/GRP78 and BCL2 at the same time and thus efficiently regulate cerebral ischemic cell death pathways.