. Author manuscript; available in PMC: 2014 Dec 1.

Published in final edited form as: Clin Cancer Res. 2013 Dec 1;19(23):10.1158/1078-0432.CCR-13-0734. doi: 10.1158/1078-0432.CCR-13-0734

Table 1.

Immune effects of chemotherapy

f	Immune Effects
Cyclophosphamide (12)	Downregulation of Treg
Doxorubicin (13)	Downregulation of PD-1
Gemcitabine (27)	Increase Class I MHC, inhibit immune suppressive cells
Paclitaxel (14)	Impair Tregs, enhances access of CTL to tumor
Methotrexate (28)	Matures dendritic cells