Table 1.
Patient | Age | Sex | Years Diagnosed | Education | UPDRS
|
MOCA
|
MMSE
|
MA Hemisphere | Medication Class | LED (mg) | Cluster Group | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OFF | ON | OFF | ON | OFF | ON | |||||||||
1 | 69 | M | 11 | 16 | 29 | 18 | 29 | 30 | 26 | 26 | L | Combination | 1038 | 1 |
2 | 61 | M | 14 | 18 | 18 | 15 | 29 | 27 | 30 | 29 | L | Combination | 1747.5 | 1 |
3 | 67 | M | 10 | 12 | 29 | 23 | 28 | 29 | 29 | 29 | R | Combination | 945.5 | 1 |
4 | 62 | F | 6 | 16 | 9 | 7 | 29 | 28 | 30 | 28 | R | Combination | 600 | 1 |
5 | 66 | M | 7 | 20 | 24 | 24 | 25 | 24 | 30 | 27 | R | Combination | 840 | 1 |
6 | 57 | M | 9 | 16 | 19 | 7 | 30 | 29 | 30 | 30 | Both | Combination | 1100 | 1 |
7 | 64 | M | 8 | 16 | 25 | 33 | 30 | 30 | 30 | 30 | R | L-DOPA | 350 | 1 |
8 | 81 | M | 1 | 14 | 23 | 18 | 25 | 25 | 28 | 29 | L | L-DOPA | 300 | 1 |
9 | 61 | M | 4 | 13 | 23 | 16 | 26 | 26 | 30 | 30 | R | L-DOPA | 900 | 1 |
10 | 72 | F | 3 | 18 | 14 | 18 | 27 | 26 | 29 | 30 | R | L-DOPA | 600 | 1 |
11 | 70 | M | 7 | 18 | --- | --- | 30 | 27 | 28 | 28 | R | L-DOPA | 698.5 | 1 |
12 | 77 | M | --- | 16 | 33 | 33 | 22 | 25 | 29 | 28 | R | L-DOPA | 400 | 1 |
13a | 69 | M | 3 | 12 | 28 | 26 | 25 | 25 | 30 | 28 | L | L-DOPA | 700 | 2 |
14 | 73 | M | 2 | 14 | 12 | 17 | 21 | 20 | 27 | 27 | L | L-DOPA | 300 | 2 |
15 | 61 | M | 5 | 16 | 22 | 16 | 19 | 20 | 28 | 28 | L | Combination | 390 | 2 |
16b | 74 | M | 5 | 14 | 17 | 20 | 27 | 26 | 29 | 28 | L | L-DOPA | 600 | 2 |
17 | 67 | M | 5 | 16 | 23 | 20 | 26 | 26 | 28 | 30 | R | L-DOPA | 1200 | 2 |
18 | 55 | M | 6 | 16 | 25 | 21 | 28 | 26 | 29 | 30 | L | Combination | 925 | 2 |
19 | 69 | M | 3 | 18 | 34 | 33 | 27 | 29 | 29 | 27 | L | L-DOPA | 300 | 2 |
20 | 65 | F | 3 | 15 | 11 | 13 | 29 | 26 | 30 | 29 | R | Combination | 600 | 2 |
21c | 84 | F | 5 | 14 | 29 | 25 | 21 | 27 | 30 | 30 | R | L-DOPA | 300 | 2 |
22 | 61 | M | 3 | 18 | 14 | 15 | 26 | 26 | 29 | 29 | L | L-DOPA | 700 | 2 |
23d | 68 | M | 1 | 16 | 15 | 14 | 22 | 30 | 29 | 29 | L | L-DOPA | 800 | 2 |
24 | 61 | M | 1 | 16 | 12 | 10 | 28 | 25 | 29 | 30 | L | L-DOPA | 250 | 3 |
25 | 63 | M | 3 | 20 | 29 | 28 | 24 | 28 | 28 | 29 | L | DA Agonist | 160 | 3 |
26e | 79 | M | 4 | 8 | 30 | 27 | 21 | 25 | 27 | 27 | L | L-DOPA | 300 | 3 |
27 | 72 | F | 8 | 13 | 18 | 18 | 25 | 22 | 28 | 30 | L | L-DOPA | 600 | 3 |
28 | 55 | M | 3 | 12 | 18 | 18 | 27 | 29 | 30 | 30 | R | L-DOPA | 898 | 3 |
| ||||||||||||||
Mean | 67.3 | 5.2 | 15.4 | 21.6 | 19.7 | 25.9 | 26.3 | 28.9 | 28.8 | 662.23 | ||||
SD | 7.5 | 3.2 | 2.6 | 7.2 | 7.2 | 3.1 | 2.7 | 1.1 | 1.2 | 357.67 |
Abbreviations: --- = No Data; UPDRS-Motor = Unified Parkinson’s Disease Rating Scale-Motor Examination; MMSE = Mini-Mental State Exam; MOCA = Montreal Cognitive Assessment; MA Hemisphere = most affected hemisphere; L-DOPA = Patients treated only with L-DOPA; DA Agonist = Patients treated with only DA agonists; Combination = Patients treated with a combination of L-DOPA and DA agonists; LED = L-DOPA equivalency dose [70]; SD = standard deviation.
Data missing for all 500 ms conditions
Data missing for the 1500 ms OFF medication condition with the more affected hand
Data missing for the 1000 and 1500 ms ON medication conditions with the less affected hand
Data missing for the 1000 ms ON medication with the more affected hand
Data missing for the 1000 ms OFF medication condition with the more affected hand