Table 2. Summary of association analysis results.
Fisher’s exact P values of < 0.05 are highlighted in bold.
| US White Mothers (307 cases, 342 controls) | US African-American Mothers (133 cases, 285 controls) | Finnish Mothers (160 cases, 200 controls) | US Hispanic Mothers (73 cases, 292 controls) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Locus | SNP | MA | OR (95CI) | P-value | OR (95CI) | P-value | OR (95CI) | P-value | OR (95CI) | P-value |
| MTNR1B | rs10830963 | G | 1.19(0.93,1.53) | 0.18 | 0.87(0.51,1.51) | 0.68 | 1.12(0.82,1.52) | 0.48 | 0.68(0.42,1.12) | 0.16 |
| IL23R | rs11465804 | G | 0.61(0.39,0.95) | 0.035 | 0.89(0.44,1.79) | 0.86 | 0.94(0.47,1.89) | 1 | 0.58(0.17,1.98) | 0.6 |
| PCSK9 | rs11591147 | T | 0.49(0.17,1.42) | 0.21 | 8.3(0.92,74.58) | 0.042 | 0.83(0.35,1.96) | 0.83 | 0.99(0.11,8.92) | 1 |
| HNF1A | rs1183910 | T | 1.09(0.86,1.40) | 0.49 | 1.23(0.83,1.84) | 0.3 | 0.94(0.69,1.28) | 0.7 | 1.08(0.74,1.59) | 0.7 |
| HLA-C | rs12191877 | T | 0.83(0.50,1.40) | 0.51 | 1.02(0.47,2.22) | 1 | 0.91(0.57,1.48) | 0.81 | NA | NA |
| LPL | rs12678919 | G | 0.59(0.39,0.88) | 0.012 | 1.23(0.77,1.98) | 0.39 | 0.89(0.53,1.50) | 0.69 | 0.88(0.4,1.93) | 0.85 |
| CELSR2, PSRC1, SORT1 | rs12740374 | T | 0.91(0.70,1.19) | 0.5 | 1.28(0.91,1.81) | 0.18 | 1.10(0.77,1.55) | 0.66 | 1.09(0.68,1.74) | 0.72 |
| LIPC | rs1532085 | A | 0.94(0.74,1.18) | 0.6 | 0.87(0.65,1.17) | 0.36 | 1.00(0.74,1.35) | 1 | 1.10(0.76,1.60) | 0.64 |
| CETP | rs1532624 | T | 0.89(0.71,1.11) | 0.32 | 0.88(0.58,1.33) | 0.6 | 0.91(0.68,1.22) | 0.55 | 1.01(0.69,1.47) | 1 |
| ICAM1 | rs1799969 | A | 1.39(0.97,1.99) | 0.08 | 0.73(0.26,2.06) | 0.63 | 1.21(0.83,1.75) | 0.34 | 0.91(0.56,1.48) | 0.81 |
| TNFSF4 | rs2205960 | T | 1.11(0.84,1.47) | 0.48 | 1.75(0.98,3.14) | 0.06 | 1.03(0.74,1.45) | 0.86 | 0.94(0.62,1.42) | 0.83 |
| KCNQ1 | rs22378924 | T | 1.24(0.67,2.28) | 0.54 | 2.72(1.30,5.69) | 0.009 | 0.73(0.36,1.48) | 0.48 | 0.57(0.32,1.04) | 0.08 |
| PTPN22 | rs2476601 | T | 0.75(0.39,1.44) | 0.4 | 0.38(0.08,1.89) | 0.31 | 0.92(0.59,1.44) | 0.74 | 1.00(0.15,6.77) | 1 |
| MSH5, HLA region | rs3131379 | A | 0.90(0.52,1.55) | 0.78 | 0.96(0.30,3.13) | 1 | 0.91(0.54,1.55) | 0.79 | NA | NA |
| ATG16L1 | rs3828309 | C | 1.17(0.94,1.47) | 0.17 | 0.93(0.66,1.31) | 0.73 | 1.11(0.82,1.49) | 0.55 | 0.89(0.59,1.34) | 0.61 |
| intronic, LCE3D, LCE3A | rs4085613 | A | 1.02(0.81,1.29) | 0.86 | 1.22(0.90,1.64) | 0.22 | 1.06(0.78,1.43) | 0.76 | 1.00(0.69,1.46) | 1 |
| APOE, APOC1, APOC4, APOC2 | rs44206382 | G | 1.11(0.82,1.50) | 0.49 | 0.96(0.66,1.40) | 0.85 | 0.82(0.59,1.14) | 0.24 | 1.19(0.64,2.24) | 0.62 |
| intronic; MMP1/3 region | rs4953664 | A | 0.82(0.64,1.06) | 0.14 | 0.96(0.70,1.30) | 0.81 | 0.93(0.67,1.28) | 0.68 | 0.94(0.65,1.36) | 0.78 |
| CDKN2A, CDKN2B | rs4977574 | G | 0.75(0.60,0.94) | 0.013 | 1.03(0.71,1.48) | 0.93 | 0.87(0.65,1.16) | 0.37 | 1.28(0.89,1.86) | 0.21 |
| G6PC2 | rs560887 | A | 0.89(0.69,1.15) | 0.36 | 1.20(0.65,2.22) | 0.63 | 1.11(0.81,1.52) | 0.52 | 1.10(0.63,1.92) | 0.77 |
| CELSR2, PSRC1 | rs599839 | G | 0.74(0.49,1.12) | 0.17 | 1.50(0.73,3.10) | 0.28 | 1.07(0.76,1.52) | 0.72 | NA | NA |
| FGB, FGA, FGG | rs6056 | T | 0.77(0.57,1.05) | 0.1 | 0.48(0.25,0.92) | 0.024 | 0.88(0.60,1.28) | 0.56 | 0.84(0.46,1.54) | 0.66 |
| MHC | rs6457617 | C | 0.69(0.49,0.99) | 0.049 | 1.11(0.65,1.91) | 0.78 | 0.96(0.71,1.30) | 0.82 | NA | NA |
| HLA-DRB1 | rs6457620 | C | 1.43(1.01,2.04) | 0.049 | 1.11(0.65,1.91) | 0.78 | 1.03(0.76,1.38) | 0.88 | NA | NA |
| LDLR | rs6511720 | T | 0.97(0.68,1.39) | 0.93 | 1.05(0.64,1.72) | 0.9 | 1.26(0.76,2.10) | 0.43 | 0.17(0.04,0.70) | 0.004 |
| INS | rs7111341 | T | 0.94(0.74,1.20) | 0.66 | 0.75(0.55,1.02) | 0.07 | 0.78(0.56,1.10) | 0.17 | 1.01(0.65,1.57) | 1 |
| CRP | rs7553007 | A | 1.00(0.79,1.28) | 1 | 1.02(0.71,1.47) | 0.93 | 1.06(0.78,1.44) | 0.76 | 0.85(0.57,1.25) | 0.43 |
| STAT4 | rs7574865 | T | 1.12(0.86,1.47) | 0.41 | 1.27(0.84,1.91) | 0.28 | 0.87(0.62,1.23) | 0.48 | 0.74(0.5,1.11) | 0.17 |
| GCKR | rs780094 | A | 1.11(0.88,1.40) | 0.38 | 1.49(1.02,2.18) | 0.044 | 1.05(0.77,1.44) | 0.81 | 1.02(0.69,1.51) | 0.92 |
| TCF7L2 | rs7903146 | T | 1.17(0.91,1.51) | 0.23 | 0.96(0.68,1.35) | 0.86 | 1.34(0.93,1.94) | 0.11 | 1.44(0.93,2.25) | 0.12 |
| FTO | rs8050136 | A | 1.00(0.79,1.26) | 1 | 1.12(0.83,1.52) | 0.49 | 1.10(0.82,1.48) | 0.55 | 1.05(0.69,1.6) | 0.83 |
| CCHCR1, HLA region | rs9263739 | T | 0.97(0.6,1.57) | 0.9 | 0.90(0.45,1.78) | 0.86 | 1.58(1.01,2.46) | 0.044 | NA | NA |
| HLA-DRA | rs9268645 | G | 1.75(1.22,2.50) | 0.003 | 0.82(0.45,1.50) | 0.55 | 0.83(0.61,1.14) | 0.27 | NA | NA |
| HLA-DQA1 | rs9272346 | G | 0.65(0.46,0.94) | 0.022 | 0.80(0.46,1.37) | 0.49 | 1.18(0.88,1.58) | 0.3 | NA | NA |
| ZNF259, APOA1, APOC3, APOA4, APOA5 | rs964184 | G | 1.29(0.94,1.79) | 0.12 | 1.05(0.72,1.53) | 0.85 | 1.18(0.78,1.79) | 0.46 | 0.58(0.38,0.9) | 0.015 |
| FTO | rs99396091,2,4 | A | 1.25(0.96,1.63) | 0.11 | 1.07(0.75,1.51) | 0.72 | 1.09(0.81,1.46) | 0.6 | 1.31(0.7,2.43) | 0.4 |
1
US white controls are out of HWE (P<0.001)
2
US African-American controls are out of HWE (P<0.001)
3
Finnish controls are out of HWE (P<0.001)
4
Hispanic controls are out of HWE (P<0.001)
SNP, single nucleotide polymorphism; MA, minor allele; OR, odds ratio; CI, confidence interval;