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. 2013 Dec 16;8(12):e81431. doi: 10.1371/journal.pone.0081431

Table 4. Type 1 error in ERF data analysis.

Not corrected Constant corrected VIFGC corrected* PGC corrected
Model Frequency λmedian λregress E λmedian λregress E λmedian λregress E λmedian λregress E
Recessive all 1.201 1.200 0.074 1.000 1.000 0.050 1.001 1.000 0.050 1.000 1.000 0.050
[0.05,0.25) 1.105 1.109 0.063 0.921 0.924 0.042 0.993 0.997 0.050 0.998 1.002 0.051
[0.25,0.5) 1.188 1.180 0.072 0.989 0.983 0.048 1.005 0.999 0.050 0.998 0.992 0.050
[0.5,0.75) 1.240 1.252 0.079 1.033 1.043 0.055 1.004 1.013 0.051 0.996 1.006 0.051
[0.75,0.95] 1.273 1.261 0.081 1.061 1.051 0.056 1.001 0.991 0.049 1.008 0.999 0.050
Additive all 1.298 1.302 0.086 1.000 1.003 0.051 0.997 1.000 0.050 0.996 1.000 0.050
[0.05,0.25) 1.299 1.290 0.085 1.001 0.994 0.050 0.998 0.991 0.049 1.008 1.000 0.050
[0.25,0.5) 1.298 1.313 0.088 1.001 1.012 0.052 0.997 1.008 0.052 0.986 0.997 0.050
[0.5,0.75) 1.301 1.320 0.088 1.003 1.017 0.053 1.000 1.014 0.052 0.989 1.003 0.051
[0.75,0.95] 1.292 1.286 0.084 0.995 0.991 0.049 0.992 0.988 0.049 1.003 0.999 0.050
Dominant all 1.202 1.203 0.074 1.000 1.001 0.050 1.000 1.000 0.050 1.000 1.000 0.050
[0.05,0.25) 1.277 1.265 0.081 1.063 1.053 0.056 1.001 0.991 0.049 1.008 0.999 0.050
[0.25,0.5) 1.243 1.252 0.079 1.035 1.042 0.054 1.003 1.011 0.051 0.997 1.005 0.051
[0.5,0.75) 1.190 1.183 0.072 0.990 0.985 0.049 1.005 1.000 0.050 0.999 0.994 0.050
[0.75,0.95] 1.104 1.112 0.064 0.919 0.925 0.042 0.991 0.998 0.050 0.995 1.002 0.051
Over-dominant all 1.133 1.123 0.064 1.000 0.991 0.049 1.011 1.000 0.050 1.011 1.000 0.050
[0.05,0.25) 1.203 1.193 0.072 1.061 1.053 0.056 1.017 1.010 0.051 1.011 1.003 0.050
[0.25,0.5) 1.076 1.060 0.057 0.950 0.935 0.043 1.011 0.995 0.049 1.013 0.998 0.049
[0.5,0.75) 1.064 1.053 0.056 0.939 0.929 0.042 1.000 0.989 0.049 1.004 0.993 0.049
[0.75,0.95] 1.204 1.190 0.072 1.062 1.050 0.056 1.017 1.007 0.051 1.014 1.004 0.051
Genotypic (df = 2) all 1.157 1.162 0.077 1.000 1.004 0.052 0.964 0.966 0.046 0.996 1.000 0.051
[0.05,0.25) 1.163 1.159 0.077 1.005 1.002 0.052 0.973 0.969 0.047 1.004 1.001 0.051
[0.25,0.5) 1.152 1.165 0.077 0.996 1.006 0.052 0.954 0.964 0.045 0.988 0.999 0.051
[0.5,0.75) 1.151 1.164 0.077 0.995 1.006 0.052 0.953 0.963 0.046 0.989 1.000 0.051
[0.75,0.95] 1.163 1.159 0.077 1.005 1.001 0.052 0.973 0.970 0.047 1.004 1.000 0.052

* for VIFGC corrected genotypic (2df) tests, we used the 1df based test by performing VIFGC-corrected tests for recessive and dominant models [3].

The abbreviations are as in Table 1. The values are given for all SNPs as well as for stratified frequency groups.