Table 2.
Selected polymorphisms
| Gene | rs number | Location | Amino acid change | Tested effect* |
|---|---|---|---|---|
| ADRA2C | rs61767072 | exon | p.Gly322_Pro325del | at risk |
| ADRB1 | rs1801252 | exon | p.Ser49Gly | protective |
| ADRB1 | rs1801253 | exon | p.Arg389Gly | protective |
| ADRB2 | rs28365031 | exon | p.Glu307_Glu309dup | at risk |
| ATP1B1 | rs10919071 | intron | - | protective |
| KCNE1 | rs1805128 | exon | p.Asp85Asn | at risk |
| KCNH2 | rs1805123 | exon | p.Lys897Thr | protective |
| KCNH2 | rs3778873 | intron | - | protective |
| KCNH2 | rs3807375 | intron | - | at risk |
| KCNH2 | rs3815459 | intron | - | at risk |
| KCNJ2 | rs17779747 | 3′downstream | - | protective |
| KCNQ1 | rs12296050 | intron | - | at risk |
| KCNQ1 | rs2074238 | intron | - | protective |
| KCNQ1 | rs757092 | intron | - | at risk |
| NOS1AP | rs10494366 | intron | - | at risk |
| NOS1AP | rs12029454 | intron | - | at risk |
| NOS1AP | rs12143842 | 5′upstream | - | at risk |
| NOS1AP | rs16857031 | intron | - | at risk |
| NOS1AP | rs4657139 | 5′upstream | - | at risk |
| NOS1AP | rs4657178 | intron | - | at risk |
| CNOT3 | rs36643 | 5′near gene | - | protective |
| PLN | rs11970286 | 5′upstream | - | at risk |
| PLN | rs12210810 | 5′upstream | - | protective |
| SCN5A | rs12053903 | intron | - | protective |
| SCN5A | rs1805124 | exon | p.His558Arg | at risk |
*
Minor alleles were considered at risk alleles when they increased QTc and the risk of cardiac events, or enhanced adrenergic responses; whereas they were considered as protective alleles when they decreased QTc and risk of cardiac events, or reduced adrenergic responses according to previous studies. Minor alleles were defined according to allele frequencies in Europeans.