Table 3.
Gene | SNP | Population | Genotypic status* | Asymptomatic | Symptomatic | p-value|| | OR [95% CI] |
---|---|---|---|---|---|---|---|
KCNQ1 | rs2074238 | Discovery† | CC | 98 (87.5%) | 106 (94.6%) | 1.98 10−3 | 0.38 [0.19–0.73] |
CT | 14 (12.5%) | 6 (5.4%) | |||||
South African | CC | 36 (87.8%) | 108 (97.3%) | 3.13 10−5 | 0.20 [0.09–0.44] | ||
CT | 5 (12.2%) | 3 (2.7%) | |||||
Finnish | CC | 109 (90.1%) | 58 (92.1%) | 0.33 | 0.78 [0.26–2.34] | ||
CT | 12 (9.9%) | 5 (7.9%) | |||||
Meta-analysis (replication‡)§ | - | - | - | 0.07 | 0.37 [0.10–1.42] | ||
Meta-analysis (Discovery and replication‡) | - | - | - | 1.68 10−3 | 0.36 [0.18 – 0.71] |
‘CC’ represents the major homozygous genotype and ‘CT’ represents the heterozygous genotype
Pooled population (Caucasian and Japanese)
South African and Finnish
heterogeneity I2=0.75, p=0.05
not corrected for multiple tests