Table 4.

QTc duration in LQTS mutation carriers according to replicated SNPs

Gene	SNP	Population	AA*		Aa and aa*		p-value**
			QTc (ms)	n	QTc (ms)	n
KCNQ1	rs2074238	Discovery†	479±44	120	464±35	18	0.04
		South African	488±43	101	467±23	6	8.14 10−3
		Finnish	465±34	152	445±31	15	2.95 10−3
		Meta-analysis (replication‡)§	474 ± 40	253	451 ± 30	21	1.37 10−4
		Meta-analysis (Discovery and replication‡)	476 ± 41	373	457 ± 33	39	3.43 10−5
NOS1AP	rs12029454	Discovery||	471±44	125	484±50	95	6.08 10−3
		South African	483±37	88	501±63	20	0.18
		Finnish	459±32	97	468±37	70	0.08
		Meta-analysis (replication‡)#	470±36	185	475±46	90	0.05
		Meta-analysis (Discovery and replication‡)	471±40	310	483±42	185	1.46 10−3

Data presented as mean ± SD

^*‘AA’ represents the major homozygous genotype (corresponding to ‘CC’ for rs2074238 and ‘GG’ for rs12029454) and ‘Aa and aa’ represents the minor allele (‘T’ for rs2074238 and ‘A’ for rs12029454) in the heterozygous or homozygous state.

^†Caucasian population (rs2074238 is not polymorphic in the Japanese population)

^‡South African and Finnish

^§Heterogeneity I²=0, p=0.74

^||Pooled population (Caucasian and Japanese)

^#Heterogeneity I²=0, p=0.84

^**not corrected for multiple tests