Table 4.
Gene | SNP | Population | AA*
|
Aa and aa*
|
p-value** | ||
---|---|---|---|---|---|---|---|
QTc (ms) | n | QTc (ms) | n | ||||
KCNQ1 | rs2074238 | Discovery† | 479±44 | 120 | 464±35 | 18 | 0.04 |
South African | 488±43 | 101 | 467±23 | 6 | 8.14 10−3 | ||
Finnish | 465±34 | 152 | 445±31 | 15 | 2.95 10−3 | ||
Meta-analysis (replication‡)§ | 474 ± 40 | 253 | 451 ± 30 | 21 | 1.37 10−4 | ||
Meta-analysis (Discovery and replication‡) | 476 ± 41 | 373 | 457 ± 33 | 39 | 3.43 10−5 | ||
NOS1AP | rs12029454 | Discovery|| | 471±44 | 125 | 484±50 | 95 | 6.08 10−3 |
South African | 483±37 | 88 | 501±63 | 20 | 0.18 | ||
Finnish | 459±32 | 97 | 468±37 | 70 | 0.08 | ||
Meta-analysis (replication‡)# | 470±36 | 185 | 475±46 | 90 | 0.05 | ||
Meta-analysis (Discovery and replication‡) | 471±40 | 310 | 483±42 | 185 | 1.46 10−3 |
Data presented as mean ± SD
‘AA’ represents the major homozygous genotype (corresponding to ‘CC’ for rs2074238 and ‘GG’ for rs12029454) and ‘Aa and aa’ represents the minor allele (‘T’ for rs2074238 and ‘A’ for rs12029454) in the heterozygous or homozygous state.
Caucasian population (rs2074238 is not polymorphic in the Japanese population)
South African and Finnish
Heterogeneity I2=0, p=0.74
Pooled population (Caucasian and Japanese)
Heterogeneity I2=0, p=0.84
not corrected for multiple tests