Figure 5. Tryptanthrin suppressed the Matrigel plug in vivo angiogenesis.
Matrigel mixed with VEGF and heparin or tryptanthrin was injected into the flanks of 6-week-old BALB/c mice (five mice per group). Seven days later, the Matrigel plugs were removed for analysis. (A) Representative appearance of Matrigel plugs. (B) Hemoglobin content of Matrigel plugs from groups of mice was quantified by using QuantiChrom™ Hemoglobin Assay Kit. Data are expressed as mean ± SD. *** p<0.001.