Table 4.

Evaluation of associations between cruciferous vegetable consumption, isothiocyanate, and colorectal cancer by glutathione S-transferase genotype

	Cases/controls	Tertile of cruciferous vegetable consumption					p trend	p int	Tertile of ITC					p trend	p int
		1		2		3			1		2		3
			OR	(95% CI)	OR	(95% CI)				OR	(95% CI)	OR	(95% CI)
GSTM1
Null	201/379	1.00	0.67	(0.42, 1.07)	1.04	(0.66, 1.63)	0.7792	0.2867	1.00	1.13	(0.72, 1.77)	1.06	(0.68, 1.65)	0.8111	0.9546
Non-null	134/259	1.00	1.04	(0.59, 1.84)	1.28	(0.73, 2.23)	0.3786		1.00	1.27	(0.72, 2.24)	1.11	(0.63, 1.94)	0.7629
GSTT1
Null	173/318	1.00	0.78	(0.48, 1.28)	1.11	(0.68, 1.81)	0.6831	0.8807	1.00	0.80	(0.49, 1.30)	1.01	(0.63, 1.63)	0.9392	0.1061
Non-null	164/350	1.00	0.90	(0.54, 1.50)	1.11	(0.67, 1.82)	0.6457		1.00	1.50	(0.92, 2.43)	0.95	(0.57, 1.59)	0.8302
GSTM1/GSTT1
Both null	106/169	1.00	0.43	(0.21, 0.87)	0.81	(0.42, 1.57)	0.6302	0.4721	1.00	0.98	(0.50, 1.90)	1.44	(0.76, 2.73)	0.2531	0.1375
One null/One non-null	159/336	1.00	0.97	(0.59, 1.61)	1.42	(0.86, 2.36)	0.1746		1.00	1.08	(0.67, 1.74)	0.71	(0.43, 1.17)	0.1919
Both non-null	67/128	1.00	1.16	(0.45, 2.96)	0.95	(0.41, 2.24)	0.8496		1.00	2.45	(0.99, 6.04)	1.79	(0.74, 4.34)	0.2342

All models adjusted for age, BMI, leisure time physical activity, total energy intake, red meat intake, total meat intake, education, income, occupation, smoking, alcohol consumption, family history of cancer, and matching variables including sample type (blood/buccal cell), collection time (morning/afternoon), time (hours) between last meal and sample collection, recent antibiotic use, and time (days) between sample collection and assays for ITC.