Skip to main content
. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: Chem Rev. 2013 May 8;113(8):6816–6863. doi: 10.1021/cr3001059

Scheme 18.

Scheme 18

Putative biosynthesis of the Mitomycinoids and FR series of compounds from UDP-glucose. Functionality of many enzymes in the pathway has been ascertained, yet several elude assignment of their roles, or the specific order in which functions are excecuted. For example, the authors have proposed that MitC be involved in deacetylation of an early adduct of AHBA and glucosamine, but it is not known at which point in the biosynthesis that the enzyme acts.