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. 2013 Sep 4;12(19):3194–3202. doi: 10.4161/cc.26241

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Copyright © 2013 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name cc-12-3194-g2.jpg — Figure 2. Aggregates formed by truncated FUS 1–359 in SH-SY5Y cells display typical characteristics of aggresomes. (A) Large juxtanuclear structures formed by FUS 1–359 are clustered around the centrosome, visualized with centrosome marker gamma-tubulin (arrowheads). (B) Anti-vimentin staining of cells expressing FUS 1–359 reveals a characteristic “vimentin cage” around large juxtanuclear structures. (C) Formation of juxtanuclear aggregates by FUS 1–359 (arrow) is prevented by nocodazole-induced disruption of microtubules. Scale bar: 15 µm for all panels.