Table 2.
Comparison of women with and without upgrade to cancer on follow-up.
| Papillary | Lobular neoplasia | ADH | ||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| N (%) Upgrade | N (%) No Upgrade | p-value | N (%) Upgrade | N (%) No Upgrade | p-value | N (%) Upgrade | N (%) No Upgrade | Characteristic |
|
| ||||||||
| 2 (2) | 97 | 18 (10) | 155 (90) | 123 (18) | 562 (82) | Total (N=957) | ||
|
| ||||||||
| Age at mammography, years | ||||||||
| 17 (100) | 4 (8) | 47 (92) | 44 (22) | 156 (78) | 40–49 (268) | |||
| 35 (100) | 8 (11) | 65 (89) | 31 (14) | 194 (86) | 50–59 (333) | |||
| 1 (4) | 24 (96) | 4 (13) | 26 (87) | 25 (18) | 118 (83) | 60–69 (198) | ||
| 1 (5) | 21 (95) | 0.74 | 2 (11) | 17 (90) | 0.28* | 23 (20) | 94 (80) | 70+ (158) |
|
| ||||||||
| Personal history of breast cancer | ||||||||
| 2 (2) | 91 (98) | 18 (11) | 152 (89) | 116 (18) | 536 (82) | No (915) | ||
| 6 (100) | NE | 3 (100) | 0.77 | 7 (21) | 26 (79) | Yes (42) | ||
|
| ||||||||
| Family history of breast cancer | ||||||||
| 2 (4) | 55 (97) | 14 (11) | 114 (89) | 81 (17) | 406 (83) | No (672) | ||
| 8 (100) | 2 (9) | 21 (91) | 27 (25) | 82 (75) | Yes (140) | |||
| 34 (100) | 0.72 | 2 (9) | 20 (91) | 0.076 | 15 (17) | 74 (83) | Unknown (145) | |
|
| ||||||||
| Menopausal status | ||||||||
| 12 (100) | 5 (9) | 51 (91) | 42 (22) | 147 (78) | Pre (245) | |||
| 2 (5) | 41(95) | 8 (15) | 45 (85) | 41 (18) | 189 (82) | Post : No Hormone treatment (283) | ||
| 21(100) | 2 (6) | 31 (94) | 15 (11) | 121(89) | With hormone treatment (169) | |||
| 23 (100) | 0.61 | 3(10) | 28 (90) | 0.037 | 25 (19) | 105 (81) | Missing (161) | |
|
| ||||||||
| Indication for mammogram | ||||||||
| 2 (2) | 84 (98) | 17 (11) | 142 (89) | 108 (18) | 499 (82) | Routine screening (852) | ||
| 13 (100) | 0.44 | 1 (7) | 13 (93) | 0.78 | 15 (19) | 63 (81) | Short interval f/u (105) | |
|
| ||||||||
| Time since last mammography | ||||||||
| 12 (100) | 3 (14) | 18 (86) | 15 (18) | 67 (82) | <1 year (115) | |||
| 2(3) | 66 (97) | 12 (9) | 118 (91) | 84 (18) | 383 (82) | 1–2 years (665) | ||
| 4 (100) | 0 | 8 (100) | 7 (14) | 45 (87) | 3–4 years (64) | |||
| 11 (100) | 2 (18) | 9 (82) | 14 (22) | 49 (78) | No previous/5+ years (85) | |||
| 4 (100) | 0.16* | 1 (33) | 2 (67) | 0.95* | 3 (14) | 18 (86) | Unknown (28) | |
|
| ||||||||
| BI-RADS breast density | ||||||||
| 3 (100) | 0 (0) | 2 (100) | 4 (17) | 20 (83) | Almost entirely fat (29) | |||
| 1 (2) | 41 (98) | 6 (14) | 36 (86) | 32 (13) | 207 (87) | Scattered fibroglandular tissue (323) | ||
| 21 (100) | 6 (8) | 68 (92) | 62 (20) | 252 (80) | Heterogeneously dense (409) | |||
| 1 (25) | 3 (75) | 4 (15) | 23 (85) | 14 (25) | 42 (75) | Extremely dense (87) | ||
| 29 (100) | 0.94 | 2 (7) | 26 (93) | 0.084* | 11 (21) | 41 (79) | Missing (109) | |
|
| ||||||||
| 17(100) | 0.41* | 0 | 16 (100) | 24 (23) | 80 (77) | Exam year | ||
| 37 (100) | 4 (10) | 38 (91) | 24 (13) | 165 (87) | 1994–1998 (137) | |||
| 2 (5) | 36 (95) | 11 (15) | 64 (85) | 54 (19) | 229 (81) | 1999–2001 (268) | ||
| 7 (100) | 3 (8) | 37 (93) | 0.73* | 21 (19) | 88 (81) | 2002–2005 (396)2006–2007 (156) | ||
|
| ||||||||
| F/u surgery† within 6 months | ||||||||
| 1 (1) | 79 (99) | 2 (2) | 103 (98) | 13 (5) | 252 (95) | No (450) | ||
| 1 (5) | 18 (95) | 0.0006 | 16 (24) | 52 (77) | <.0001 | 110 (26) | 310 (74) | Yes (507) |
*
trend test continuous.
†
including excisional biopsies, lumpectomies, and mastectomies
ADH-atypical ductal hyperplasia
BI-RADS- Breast Imaging-Reporting and Data System