Figure 2.

SAT performance of CHT+/− and WT mice at baseline and prior to cannulation surgery. a: Illustration of trial types (signal and non-signal, respectively; pseudo-randomized sequence) and outcomes (note that half of the animals were trained with reversed outcome assignments to response ports). b: The SAT score indicates overall performance by combining signal and non-signal trial performance (see Methods). SAT scores vary by signal duration, reflecting higher hit rates to longer signals. SAT scores did not indicate an effect of genotype. The number of correct rejections was slightly but significantly lower in CHT+/− mice (see Results for ANOVA and means) and decreased for all animals toward the end of the session (see c). This effect of block did not interact with genotype. d: The number of errors of omission increased towards later blocks of trials, with blocks 3-5 containing more omissions than blocks one and two and additional significant differences between blocks 3, 4 and 5 (multiple comparisons, for this and subsequent figures: *, p<0.05; **, p<0.001).