Table 2.

Summary of correlations amongst studied variables in patients with dry eye disease

	Number of cases	Mean age	Gender	Mean TOsm* value at baseline	Mean CFS value at baseline	Mean OSDI value at baseline	Coefficient of correlation	P value
All cases
CFS-OSDI	146	53±15	F (64%)	-	1.8±1.2	45.3±23.0	0.31	<0.001
TOsm-CFS	135	54±15	F (64%)	312.1±19.3	1.6±1.2	-	−0.02	0.80
TOsm-OSDI	97	53±14	F (60%)	312.8±19.5	-	43.0±21.8	−0.091	0.38
OSDI >12
CFS-OSDI	138	53±15	F (64%)	-	1.8±1.2	47.5±21.7	0.30	<0.001
TOsm-CFS	94	53±15	F (62%)	312.2±19.4	1.6±1.2	-	0.02	0.84
TOsm-OSDI	90	52±14	F (61%)	312.6±19.3	-	45.8±20.1	−0.10	0.36
TOsm > 308*
CFS-OSDI	66	53±13	F (64%)	-	1.8±1.1	45.3±21.6	0.35	0.005
TOsm-CFS	71	53±14	F (63%)	326.5±13.7	1.8±1.2	-	−0.07	0.59
TOsm-OSDI	53	52±13	F (57%)	326.8±13.3	-	42.8±19.9	0.003	0.98
MCID OSDI (>4.5)
CFS-OSDI	66	56±15	F (61%)	-	1.7±1.2	36.7±17.8	0.46	<0.001
TOsm-CFS	35	52±14	F (57%)	315.5±19.0	1.6±1.0	-	−0.09	0.58
TOsm-OSDI	37	54±15	F (59%)	315.8±19.4	-	37.6±18.7	−0.12	0.47

^*mOsm/l. TOsm, tear osmolarity; OSDI, Ocular Surface Disease Index©; CFS, Corneal fluorescein staining; MCID, minimal clinically important difference.