Table 2. Classification of rats by cocaine-induced locomotor activity.
Acute Cocaine Groups Acute 1 and Acute 2 | ||||
---|---|---|---|---|
Group | Classification |
Habituation LMA
(cm/30 min) |
Cocaine LMA
(cm/30 min) |
|
Baseline Mean | Mean | Median | ||
Acute 1 | Vehicle (n = 8) | 83 ± 36 | 342 ± 65 | |
Acute 2 | Vehicle (n = 6) | 109 ± 50 | 569±140 | |
Acute 1 | Cocaine (n = 16) | 135 ± 48 | 880±120 | |
Acute 2 | Cocaine (n = 18) | 78 ± 41 | 1088±330 | |
Acute 1 | LCR (n = 8) | 226±120 | 347±102 | 772 |
HCR (n = 8) | 95 ± 59 | 1413±180 | ||
Acute 2 | LCR (n = 9) | 74 ± 64 | 429 ± 74 | 813 |
HCR (n = 9) | 81 ± 55 | 1747 ± 590 |
Comparison of cocaine-induced locomotor activity (10 mg/kg, i.p.) in all rats and rats classified as LCRs and HCRs in groups Acute 1 and Acute 2. Data are presented as mean values ± SEM and represent the sum of activity over the first 30 min post-injection.