. Author manuscript; available in PMC: 2014 Dec 1.

Published in final edited form as: Neuropharmacology. 2013 Aug 22;0:10.1016/j.neuropharm.2013.08.001. doi: 10.1016/j.neuropharm.2013.08.001

Table 3. Western blot analysis of dSTR and NAc mGluR5 and mGluR2/3 in cocaine self-administering LCR/HCR rats following extinction/reinstatement tests.

Group: SA1	Striatal Subregion
Group: SA1	dSTR		NAc
Protein (Ratio to α-tubulin)	LCR	HCR	LCR	HCR
Monomeric mGluR5	0.58 ± 0.06	0.59 ± 0.07	0.97 ± 0.27	0.71 ± 0.12
Heteromeric mGluR5	0.34 ± 0.03	0.53 ± 0.06*	1.31 ± 0.19	1.20 ± 0.15
Monomeric mGluR2/3	0.82 ± 0.23	0.96 ± 0.18	ND	ND
Heteromeric mGluR2/3	1.34 ± 0.14	1.35 ± 0.23	ND	ND

Group: SA2	Striatal Subregion
Group: SA2	dSTR		NAc
Protein (Ratio to α-tubulin)	LCR	HCR	LCR	HCR
Monomeric mGluR5	1.12 ± 0.08	1.29 ± 0.06	1.68 ± 0.25	1.39 ± 0.21
Heteromeric mGluR5	0.79 ± 0.06	0.99 ± 0.07*	1.65 ± 0.23	1.36 ± 0.19
Monomeric mGluR2/3	0.71 ± 0.13	0.51 ± 0.14	ND	ND
Heteromeric mGluR2/3	1.09 ± 0.11	1.04 ± 0.11	ND	ND

Values shown in groups SA1 and SA2 are the ratio of mGluR protein immunoreactivity to a-tubulin loading control immunoreactivity. Data are presented as mean values ± SEM. *p < 0.05. ND = not determined.