Table 4. Western blot analysis of mGluR5 in dSTR and NAc from acute cocaine LCR, HCR, and vehicle (VEH) rats 24 h following treatment.
Group:
Acute 1 |
Striatal Subregion | |||||
---|---|---|---|---|---|---|
dSTR | NAc | |||||
Protein
(Ratio to α- tubulin) |
VEH | LCR | HCR | VEH | LCR | HCR |
Monomeric | 1.90 ± 0.73 | 1.38 ± 0.33 | 0.90 ± 0.25 | 1.65 ± 0.26 | 2.00 ± 0.60 | 1.68 ± 0.40 |
Heteromeric | 1.53 ± 0.18 | 1.40 ± 0.11 | 1.59 ± 0.27 | 2.03 ± 0.23 | 1.90 ± 0.26 | 2.19 ± 0.34 |
Group:
Acute 2 |
Striatal Subregion | |||||
---|---|---|---|---|---|---|
dSTR | NAc | |||||
Protein
(Ratio to α- tubulin) |
VEH | LCR | HCR | VEH | LCR | HCR |
Monomeric | 2.35 ± 0.24 | 2.28 ± 0.38 | 2.27 ± 0.24 | 2.09 ± 0.47 | 1.89 ± 0.18 | 2.10 ± 0.15 |
Heteromeric | 1.03 ± 0.16 | 1.12 ± 0.10 | 1.15 ± 0.11 | 1.49 ± 0.10 | 1.56 ± 0.35 | 1.65 ± 0.13 |
Values shown in groups Acute 1 and Acute 2 are the ratio of mGluR protein immunoreactivity to α-tubulin loading control immunoreactivity. Data are presented as mean values ± SEM.