Fig. 4.

Effects of prolonged selective 5-HT reuptake inhibitors citalopram and paroxetine on L-DOPA reversal of motor deficit in L-DOPA-naïve rats using the forepaw adjustment steps test. Baseline stepping deficits were established 3 weeks post-lesion. Rats then received daily treatment with vehicle, citalopram (3 or 5 mg/kg, s.c.), or paroxetine (0.5 or 1.25 mg/kg, s.c.) 30 min prior to L-DOPA (6 mg/kg, s.c.) + benserazide (15 mg/kg, s.c.) for 22 days. Forepaw adjusting steps were evaluated 60 min after treatments on days 3, 10, and 17. Values (as means + standard mean error; S.E.M.) are expressed as percent intact vs. intact forepaw. Significant differences were evaluated by 1-way ANOVAs for baseline stepping across groups and within each treatment condition. When appropriate, motor performance differences across test days were analyzed with Fisher LSD post-hocs. * p < 0.05 vs. Baseline, + p < 0.05 vs. Sham-Vehicle.