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. 2013 Dec 16;8(12):e83560. doi: 10.1371/journal.pone.0083560

Figure 4. Kim53ΔJ+P induces cross-protection against Y. enterocolitica and F. tularensis.

Figure 4

(A) Mice were either only infected i.p. with 1×103 cfu of Y. enterocolitica WA (square, six mice/group) or infected s.c. with 1×104 cfu of Kim53ΔJ+P and challenged i.p. with 1×103 cfu of Y. enterocolitica WA three days later (circle, six mice/group). (B) Mice were either only infected either i.p. with 500 cfu of F. tularensis LVS (square, ten mice/group) or infected s.c. with 1×104 cfu of Kim53ΔJ+P and challenged i.p. with 500 cfu of F. tularensis LVS three days later (circle, ten mice/group). (C) Mice were either only infected i.n. with 5000 cfu of F. tularensis LVS (square, eight mice/group) or infected s.c. with 1×104 cfu of Kim53ΔJ+P and challenged i.n. with 5000 cfu of F. tularensis LVS three days later (circle, ten mice/group). Mortality was monitored for 16 days post-challenge.