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Frequencies, activation status, and functionality of bulk CD4+ and CD8 + T cells in the blood and gut mucosal compartments in healthy control individuals. (a–c) CD4+ and (d–f) CD8 + T cells are quantified and examined for expression of human leukocyte antigen (HLA)-DR and CCR5 in both the blood and gut compartments. (g–i) Cytokine production by CD4 + T cells from both the compartments after stimulation are plotted. Heavy lines represent the medians. IFN, interferon; IL, interleukin.
