Table 1. Clinicopathological characteristics of patients with advanced gastric cancer.
| Characteristics | Non-curative surgery + first-line chemotherapy | First-line chemotherapy only | P |
| No. of patients | 414 | 323 | |
| Age(years, median, range) | 55(23–84) | 55(19–84) | 0.988 |
| < 70 year | 378(91.3) | 298(92.3) | 0.640 |
| ≥ 70 year | 36(8.7) | 25(7.7) | |
| Sex, n | 0.175 | ||
| Men | 280 (67.6) | 203 (62.8) | |
| Women | 134 (32.4) | 120 (37.2) | |
| Charlson score | 0.354 | ||
| 0 | 5(1.2) | 4( 1.1) | |
| 1 | 404(97.6) | 300 (93) | |
| 2 | 5(1.2) | 19 (5.9) | |
| Tumor location | 0.265 | ||
| Proximal | 275 (66.4) | 227 (70.3) | |
| Distal | 139 (33.6) | 96 (29.7) | |
| Histological grade | 0.252 | ||
| High-differentiation | 5(1.2) | 7(2.2) | |
| Moderate-differentiation | 51(12.3) | 49(15.2) | |
| Low-differentiation | 267(64.5) | 211(65.3) | |
| Poor-differentiation | 91(22.0) | 56(17.3) | |
| Gloss type | 0.118 | ||
| Protrusion | 87 (21.0) | 89 (27.6) | |
| Ulcer | 265(64.0) | 190 (58.8) | |
| Infiltration | 62 (15.0) | 44 (13.6) | |
| Size | 0.625 | ||
| <5 cm | 195(47.1) | 158(48.9) | |
| ≥5 cm | 219(52.9) | 165(51.1) | |
| Serum CEA(ng/ml, median, range) | 2.4(0.2–6576.0) | 3.6(0.3–7617.0) | 0.008 |
| Serum CA19-9(U/ml, median, range) | 12.6(0.6–12210.0) | 28.1(0.6–20000.0) | 0.000 |
| Serum CA72-4(U/ml, median, range) | 2.8(0.6–1298.0) | 7.9(0.7–1425.0) | 0.000 |
| Hemoglobin(g/l, median, range) | 120.2(78–168) | 122.6(83–162) | 0.522 |
| Albumin(g/l, median, range) | 38.8(24.9–49.0) | 38.3(17.3–54.0) | 0.306 |
| ALT(U/L, median, range) | 16.8(3.4–87.0) | 15.9(0.9–88.3) | 0.270 |
| AST(U/L, median, range) | 19.5(10.3–90.9) | 20.2(6.1–93.3) | 0.235 |
| Tbil(mmol/l, median, range) | 9.0(2.8–28.0) | 9.5(2.6–29) | 0.520 |
| Ascites | 0.000 | ||
| Yes | 17(4.1) | 53(17.0) | |
| No | 396(95.9) | 270(83.0) | |
| Second-line chemotherapy | 0.000 | ||
| Yes | 121(29.2) | 144(44.6) | |
| No | 293(70.8) | 179(55.4) |
Abbreviations: CEA, baseline carcinoembryonic antigen; CA19-9, baseline carbohydrate antigen 19-9; CA72-4, baseline carbohydrate antigen 72-4; ALT, baseline alanine aminotransferase; AST, baseline aspartate aminotransferase; Tbil, baseline total bilirubin.