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. 2013 Dec 17;4:511. doi: 10.3389/fpls.2013.00511

FIGURE 1.

FIGURE 1

The ROP11-MIDD1 pathway produces the microtubule-depolymerizing domain. (A) MIDD1 links plasma membrane, cortical microtubules, and AtKinesin-13A. ROP11 is locally activated by ROPGEF4 and ROPGAP3. The activated ROP11 (GTP-ROP11) recruits MIDD1 to the plasma membrane, which in turn binds cortical microtubules. MIDD1 subsequently recruits AtKinsein-13A (Kin13A), which depolymerizes the cortical microtubule. (B) Locally activated ROP11 recruits MIDD1 to the plasma membrane domains. MIDD1 subsequently induces microtubule disassembly by recruiting AtKinesin-13A, resulting in the formation of secondary wall pits.