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. 2013 Dec 16;210(13):2793–2802. doi: 10.1084/jem.20131121

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© 2013 dos Santos et al.

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Figure 2. — Mechanisms of proteolysis of PML-RARa by ATRA and ATO. ATRA induces degradation of RARa and PML-RARa via the RARa moiety. ATO induces degradation of PML and PML-RARa via the PML moiety.