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. 2013 Dec 16;210(13):2981–2990. doi: 10.1084/jem.20130417

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© 2013 Firth et al.

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Figure 7. — Nfil3 expression is dispensable in mature NK cells. (A) Schematic of the Nfil3^fl/fl × R26Y × Ub^Cre-ERt2 mouse system for tamoxifen-inducible, Cre/loxP-mediated deletion of the Nfil3 gene. (B) Nfil3 gene deletion after tamoxifen treatment was confirmed by PCR in sorted YFP⁺ or YFP⁻ NK cells. WT NK cells were sorted as a positive control for Nfil3 gene detection. (C) Nfil3^fl/fl × R26Y × Ub^Cre-ERt2 mice were treated with tamoxifen and mature NK cells were sorted and transferred into WT recipient mice. The presence of transferred cells determined at indicated time points after transfer. Error bars for all graphs show SEM and data are representative of n = 3–4 mice per group, and experiments were independently repeated three times.