Figure 5.

Restoration of the light-evoked activity in the inner retina. A, Top: Section traversing the center of the 2-d-old lesion stained for glutamate (red), AGB (green), and GABA (blue). Bottom: Same section with the major retinal cell types identified through CMP clustering. The color coding is as follows: horizontal cells are shown in orange, hyperpolarizing cone bipolar and depolarizing rod bipolar cells in red, depolarizing cone bipolar cells in dark blue, GABAergic amacrine cells in magenta, glycinergic amacrine cells in green, and ganglion cells in light blue. The black bar at the top of the panel indicates the area of destroyed photoreceptors; gray bar shows the zone of surviving photoreceptors with detached or damaged outer segments. B, Section traversing the center of the 2-month-old lesion. Same antibody staining and cell classifications as for the acute lesion are shown. Yellow color in both classification panels indicates location of rhodopsin.