. Author manuscript; available in PMC: 2014 Dec 30.

Published in final edited form as: Psychiatry Res. 2013 Oct 18;214(3):10.1016/j.pscychresns.2013.08.007. doi: 10.1016/j.pscychresns.2013.08.007

Table 2. Summary of analyses and coordinates of regions of interest.

Analysis	Direction	Region of Interest	T score, P value, cluster size(kE)	MNI coordinates (x/y/z)
Non-depressed vs. depressed elderly at baseline	Depressed>Non-depressed	Precuneus	T=3.2, p=0.001 uncor, kE =185	6.10/49.2/11.5
Non-depressed vs. depressed elderly at baseline	Non-depressed>Depressed	Middle frontal gyrus (right &left)	T=3.17, p=0.001 uncor; kE= 33 (right)/20 (left)	30/48/14 (right) −20/62/10 (left)
Depressed elderly pre-treatment vs. post-treatment	Pre-treatment>post-treatment	Precuneus (right/left)	T=5.08, p<0.05 FDR-ROI, kE>5	16.6/−43,8/8 −2.3/−78.5/40
		Left Insula	T=3.55, p<0.05 FDR-ROI, kE>5	−41.8/10.5/−6.8
		Left Hippocampus	T=4.8, p<0.05 FDR-ROI, kE>5	−29.1/−38.4/2.01
	Post-treatment>Pre-treatment	Medial frontal gyrus (right/left)	T=6.55, p<0.05 FDR-ROI, kE>5	40/−16/64 −36/−16/66
	Post-treatment>Pre-treatment	Dorsal ACC	T=5.17, p<0.05 FDR-ROI, kE>5	5.4/4.4/46.9
Treatment-responsive vs. treatment nonresponsive depressed elderly^*	Treatment non-responsive> Treatment responsive	Cuneus	T=2.39, p=0.004, kE=1069	8/−88/14
	Treatment non-responsive> Treatment responsive	Dorsal ACC	T=2.16, p=0.02, kE=142	−4/4/32
	Treatment responsive> Treatment nonresponsive	Medial prefrontal cortex	T=2.52, p=0.01, kE=75	2/66/0
	Treatment responsive> Treatment nonresponsive	Precuneus	T=2.97, p=0.004, kE= 722	−2/−66/34
Treatment-responsive vs. treatment nonresponsive depressed elderly^**	Treatment nonresponsive > Treatment responsive	Left striatum	T=4.14, p<0.05 FDR-ROI, kE>5	−11.9/5.1/−6.8
	Treatment responsive>Treatmentnonresponsive	dlPFC (right)	T =2.09, p=0.02, kE=17	50/10/48
Treatment-responsive vs. treatment nonresponsive depressed elderly, with RBANS as covariate	Treatment nonresponsive> Treatment responsive	Thalamus (right/left)	T =4.74, p= 0.001, kE=58(right)/31 (left)	7.8/−26.8/−2 =−11.23/-25.4/−2
		Left Striatum	T =5.4, p< 0.001, kE=21	−13.2/−0.3/−6.1
		Midbrain	T =4.56, p= 0.001, kE=20	6.4/−27.5/−1.3
	Treatment responsive> Treatment nonresponsive	Superior frontal gyrus	T= 4.53, p=0.001, kE =7	18.7/43.9/50

using baseline scan (T1) as outcome variable;

^**

using the difference between the 12-week scan and the baseline scan (T2-T1) as outcome variable; Legend: MNI=Montreal Neurologic Institute; FDR=false discovery rate; ROI=region of interest; kE=cluster size; ACC = anterior cingulate cortex; dlPFC= dorsolateral prefrontal cortex.