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. Author manuscript; available in PMC: 2013 Dec 17.
Published in final edited form as: Curr Pharm Des. 2012;18(14):1934–1947. doi: 10.2174/138161212799958422

Fig. (2).

Fig. (2)

UV-Thermal melting studies of the ligands in Fig. (1) with Tel24 (black bars), AATT duplex sequence (grey bars) and (CG)4 duplex sequence (line bars). Full DNA sequences are listed in Fig. (1). The Tm values plotted are for the drug:DNA ratio of 4:1 with Tel24 and 2:1 with hairpin-DNA. The Tm of ligand-free Tel24, AATT and (CG)4 are 67, 69 and 63 °C respectively. Distamycin and RHPS4 (structures not shown) are employed as reference compounds. The thermal melting values reported are reproducible within ±1 °C.