Table 1. Morphometric data and results of distribution of 32D muFLT3-ITD cells with and without KDELR1 knockdown in hematopoietic organs.
Naive C3H mice (N=4) | 32D muFlt3-ITD sh control (N=6) | 32D muFlt3-ITD sh KDELR1 (N=7) | |
---|---|---|---|
Morphometric data | |||
Body weight (g) | 21.7±1.4 | 20.4±3.2 | 21.2±2.9 |
Liver weight (g) | 1.18±0.07 | 2.25±0.35* | 1.67±0.15*,$ |
Spleen weight (g) | 0.09±0.01 | 0.44±0.03* | 0.30±0.12*,$ |
% GFP-positive cells | |||
Spleen | — | 16.4+3.1 | 8.1±5.0$ |
bone marrow (mobile) | — | 44.6+5.4 | 26.7±14.0$ |
bone marrow (fixed) | — | 44.8+3.9 | 32.6±18.1 |
One-way ANOVA was performed and post hoc comparisons were made with the Holm–Sidak test; *$P<0.05. *Significant differences between naive C3H mice vs mice injected with 32D muFLT3-ITD control shRNA cells or injected with 32D muFLT3-ITD control shRNA cells with KDELR1 knockdown, $Significant differences between mice injected with 32D muFLT3-ITD control shRNA cells vs mice injected with 32D muFLT3-ITD control shRNA cells with KDELR1 knockdown. Data are given in mean±s.d.