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. 2013 Jul 2;1(4):206–222. doi: 10.1002/mgg3.24

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© 2013 The Author. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Protein alignment performed with ClustalW (http://www.ebi.ac.uk/Tools/msa/clustalw2) (Chenna et al. 2003). On top, the CACNA1A Thr501 residue is conserved in all the human calcium channel α1 subunits studied (CACNA1A, B, C, D, E, F, and S) and in the orthologous CACNA1A proteins of several organisms. Bottom, the ATP1A2 Glu825 residue is conserved in the four human ATP1 paralogous subunits (ATP1A1, A2, A3, and A4) and in orthologous ATP1A2 proteins of several organisms. Key: “*” identical residues; “:” conserved substitutions (same amino acid group); “.” semi-conserved substitution (similar shapes). Human: Homo sapiens; Bovin: Bos taurus; Rat: Rattus norvegicus; Mouse: Mus musculus; Fish (Zebrafish): Danio rerio.