Table 2.

Characteristics of the Eligible Studies

Author	Year	Country	Ethnicity	Sex	Age (mean±SD)	Menopausal status	BMD instrument	Study design	No. of subjects	Polymorphism	BMD measurement	Covariates	Quality score
Lorentzon et al.	2000	Sweden	European	Male	16.9±0.3	None	DPX-L	Population-based C	90	−174G/C	FN, LS, WB, Humerus	None	6
Ferrari et al.	2001	USA	Mixeda	Female	71.9±5.6	Postmenopausal	QDR-4500	Population-based C	434	−174G/C	FN, TH, TR, 1/3R, MID, UDR	Age	7
Ota et al.	2001	Japan	Asian	Female	73.2±5.8	Postmenopausal	DPX-L	Population-based CS	470	−634C/G	Radial bone	Age, height, weight	5
Fontova et al.	2002	Spain	European	Female	59.0±4.7	Postmenopausal	DPX-L	Hospital-based CC	94	−174G/C	FN, TR, WT, LS	None	6
Garnero et al.-a	2002	France	European	Female	40.0±6.2	Premenopausal	QDR-2000	Population-based C	255	−174G/C	FN, TH, TR, WT, LS, WB, DR, MID, UDR	None	8
Garnero et al.-b	2002	France	European	Female	64.0±8.6	Postmenopausal	QDR-2000	Population-based C	372	−174G/C	FN, TH, TR, LS, WB, DR, MID, UDR	None	8
Chung et al.	2003	Korea	Asian	Female	37.7±6.7	Premenopausal	Lunar Pixi	Hospital-based CS	331	−634C/G	1/3R	None	7
Ferrari et al.	2003	USA	Mixeda	Female	71.9±5.9	Postmenopausal	QDR-4500	Population-based C	451	−174G/C	LS	Age	6
Yamada et al.-a	2003	Japan	Asian	Female	46.2±5.0	Premenopausal	DQR-4500, Desiscan 1000	Population-based C	279	−634C/G	FN, TR, WT, LS, WB	Age, BMI	8
Yamada et al.-b	2003	Japan	Asian	Female	64.0±8.6	Postmenopausal	DQR-4500, Desiscan 1000	Population-based C	817	−634C/G	FN, TR, WT, LS, WB	Age, BMI	8
Yamada et al.-c	2003	Japan	Asian	Male	59.2±10.9	None	DQR-4500, Desiscan 1000	Population-based C	1126	−634C/G	FN, TR, WT, LS, WB	Age, BMI	8
Ferrari et al.-a	2004	USA	Mixeda	Female	59.5±9.2	Mixedb	DPX-L	Population-based C	816	−174G/C, −634C/G	FN, TR, WT	None	8
Ferrari et al.-b	2004	USA	Mixeda	Male	60.1±9.5	None	DPX-L	Population-based C	835	−174G/C, −634C/G	FN, TR, WT	None	8
James et al.-a	2004	UK	European	Female	60.7±0.0	Postmenopausal	QDR-4500	Population-based CRT	35	−174G/C	TH, WT, LS	None	7
James et al.-b	2004	UK	European	Female	60.7±0.0	Postmenopausal	QDR-4500	Population-based CRT	30	−174G/C	TH, WT, LS	None	7
Moffett et al.	2004	USA	European	Female	73.0±5.0	Postmenopausal	QDR-1000	Population-based C	3376	−174G/C	FN, TH, DR, PR	Age, BMI, estrogen use, study centerc	8
Nordström et al.	2004	Sweden	European	Female	75.0±0.0	Postmenopausal	DPX-L	Population-based C	964	−174G/C	FN, LS, WB	None	7
Li et al.	2008	China	Asian	Female	10.0±0.7	Premenarche	QDR-4500	Population-based CS	176	−634C/G	FN, TH, LS, WB	None	7
Czerny et al.-a	2010	Poland	European	Female	63.3±5.1	Postmenopausal	Lunar Densitometer	Hospital-based CC	226	−174G/C	FN, LS	None	5
Czerny et al.-b	2010	Poland	European	Female	64.8±6.3	Postmenopausal	Lunar Densitometer	Hospital-based CC	224	−174G/C	FN, LS	None	6
Deveci et al.	2012	Turkey	European	Female	57.0±7.0	Postmenopausal	NA	Hospital-based CC	356	−174G/C	TH, LS	None	5
Oishi et al.-a	2012	Japan	Asian	Female	19.3±1.0	Premenopausal	Prodigy Advance	Population-based CS	100	−634C/G	FN, LS, WB	None	4
Oishi et al.-b	2012	Japan	Asian	Female	68.1±4.8	Postmenopausal	QDR-A	Population-based CS	100	−634C/G	FN, LS, WB	Age, height, weight	6

^aMixed ethnicities, >94% Caucasians.

^bEighty-five percent were postmenopausal women.

^cUnadjusted BMD was also available.

C, cohort; CS, cross-sectional study; CC, case–control study; CRT, cross-sectional on randomized control trial; FN, femoral neck; LS, lumbar spine; WB, whole body; TH, total hip; TR, trochanter; 1/3R, one-third distal radius; MID, mid-distal radius; UDR, ultradistal radius; WT, Ward's triangle; DR, distal radius; PR, proximal radius; NA, not available; SD, standard deviation; BMI, body mass index.