. 2013 Dec;17(12):898–909. doi: 10.1089/gtmb.2013.0223

Table 4.

WMDS (95% CIs) and I² for Various Contrasts of IL-6 −174G/C Polymorphism and Bone Mineral Density

			CC vs. GG		CG vs. GG		CC vs. CG		CC+CG vs. GG		CC vs. CG+GG
BMD	Population^a	No. of studies (sample size)	WMD (95% CI)	I²(%)	WMD (95% CI)	I²(%)	WMD (95% CI)	I²(%)	WMD (95% CI)	I²(%)	WMD (95% CI)	I²(%)
Femoral neck^b
Overall		11 (7596)	0.001 (0.001 to 0.001)^c	26.2	0.007 (−0.003 to 0.017)	50.4^d	−0.002 (−0.002 to −0.002)^c	0.0	0.008 (−0.002 to 0.017)	49.7^d	−0.001 (−0.001 to −0.000)^c	0.0
Subgroup	European	8 (5601)	0.001 (0.001 to 0.001)^c	41.3	0.010 (−0.006 to 0.026)	65.7^d	−0.002 (−0.002 to −0.002)^c	0.0	0.010 (−0.004 to 0.024)	63.4^d	−0.001 (−0.001 to −0.000)^c	0.0
	Female	9 (6761)	0.001 (0.001 to 0.001)^c	0.0	0.005 (−0.005 to 0.014)	42.8^d	−0.002 (−0.002 to −0.002)^c	0.0	0.002 (0.002 to 0.003)^c	36.5	−0.001 (−0.001 to −0.000)^c	0.0
	Postmenopausal	7 (5690)	0.001 (0.001 to 0.001)^c	0.0	0.003 (0.003 to 0.003)^c	28.2	−0.002 (−0.002 to −0.002)^c	0.0	0.002 (0.002 to 0.003)^c	1.7	−0.001 (−0.001 to −0.000)^c	0.0
	High quality	10 (7370)	0.001 (0.001 to 0.001)^c	32.7	0.006 (−0.004 to 0.016)	51.7^d	−0.002 (−0.002 to −0.002)^c	0.0	0.007 (−0.002 to 0.016)	51.0^d	−0.001 (−0.001 to −0.000)^c	0.0
Lumbar spine^b,e
Overall		9 (3032)	0.011 (−0.009 to 0.031)	39.8	0.007 (−0.009 to 0.022)	37.9	0.007 (−0.011 to 0.026)	0.0	0.007 (−0.007 to 0.021)	40.7	0.015 (−0.001 to 0.031)	0.0
Subgroup	European	8 (2581)	0.011 (−0.009 to 0.031)	39.8	0.007 (−0.009 to 0.022)	37.9	0.007 (−0.011 to 0.026)	0.0	0.007 (−0.007 to 0.021)	40.7	0.010 (−0.008 to 0.027)	0.0
	Female	8 (2942)	0.003 (−0.018 to 0.024)	0.0	0.003 (−0.013 to 0.019)	32.5	0.004 (−0.016 to 0.023)	0.0	0.003 (−0.011 to 0.017)	17.9	0.011 (−0.006 to 0.028)	0.0
	Postmenopausal	7 (2687)	−0.003 (−0.027 to 0.020)	0.0	−0.002 (−0.021 to 0.018)	39.5	0.001 (−0.021 to 0.023)	0.0	−0.002 (−0.019 to 0.014)	15.6	0.009 (−0.010 to 0.027)	4.7
	High quality	7 (2450)	0.017 (−0.020 to 0.053)	58.2^d	0.010 (−0.017 to 0.037)	56.6^d	0.007 (−0.013 to 0.027)	0.0	0.008 (−0.015 to 0.032)	55.9^d	0.014 (−0.003 to 0.032)	37.8
Trochanter^b
Overall		6 (2716)	0.013 (−0.001 to 0.026)	34.4	0.012 (0.002 to 0.021)^c	0.0	0.001 (−0.012 to 0.014)	0.0	0.011 (0.002 to 0.020)^c	22.6	0.006 (−0.006 to 0.018)	19.4
Subgroup	European	3 (721)	0.018 (−0.003 to 0.039)	58.6	0.018 (0.003 to 0.033)^c	55.8	−0.001 (−0.021 to 0.019)	0.0	0.012 (−0.013 to 0.036)	62.0^d	0.007 (−0.012 to 0.026)	3.2
	Female	5 (1971)	0.019 (0.004 to 0.034)^c	0.0	0.013 (0.002 to 0.024)^c	8.7	0.006 (−0.009 to 0.020)	0.0	0.013 (0.003 to 0.023)^c	27.2	0.012 (−0.002 to 0.025)	0.0
	Postmenopausal	3 (900)	0.013 (−0.009 to 0.035)	24.2	0.007 (−0.008 to 0.023)	0.0	0.006 (−0.015 to 0.027)	40.6	0.006 (−0.008 to 0.020)	0.0	0.009 (−0.011 to 0.029)	43.4
Total hip
Overall		5 (4793)	0.000 (−0.000 to 0.000)	33.4	0.004 (0.004 to 0.004)^c	47.5	−0.004 (−0.004 to −0.004)^c	0.0	0.009 (−0.004 to 0.023)	56.1^d	−0.002 (−0.003 to −0.002)^c	0.0
Subgroup	European	4 (4359)	0.000 (−0.000 to 0.000)	40.9	0.010 (−0.007 to 0.027)	60.6^d	−0.004 (−0.004 to −0.004)^c	0.0	0.010 (−0.007 to 0.028)	66.8^d	−0.002 (−0.003 to −0.002)^c	0.0
	Postmenopausal	4 (4538)	0.000 (−0.000 to 0.000)	0.0	0.004 (0.004 to 0.004)^c	0.0	−0.004 (−0.004 to −0.004)^c	0.0	0.003 (0.003 to 0.003)^c	0.0	−0.002 (−0.003 to −0.002)^c	0.0
	High quality	4 (4437)	0.000 (−0.000 to 0.000)	48.2	0.009 (−0.006 to 0.025)	60.5^d	−0.004 (−0.004 to −0.004)^c	0.0	0.010 (−0.006 to 0.027)	67.0^d	−0.002 (−0.003 to −0.002)^c	1.5
Whole body
Overall		4 (1681)	0.015 (−0.005 to 0.035)	55.4^d	0.012 (−0.008 to 0.032)	70.8^d	0.006 (−0.006 to 0.018)	0.0	0.013 (−0.006 to 0.032)	71.6^d	0.008 (−0.003 to 0.019)	0.0
Subgroup	Female	3 (1591)	0.007 (−0.006 to 0.019)	42.1	0.007 (−0.013 to 0.028)	73.6^d	0.006 (−0.007 to 0.018)	0.0	0.008 (−0.010 to 0.027)	71.9^d	0.006 (−0.005 to 0.017)	0.0
	Postmenopausal	2 (1336)	0.035 (0.012 to 0.059)^c	0.0	0.024 (0.007 to 0.042)^c	0.0	0.009 (−0.012 to 0.031)	0.0	0.027 (0.010 to 0.043)^c	0.0	0.020 (−0.000 to 0.041)	0.0
Ward's triangle^b
Overall		4 (1910)	0.020 (−0.002 to 0.042)	32.5	0.020 (0.004 to 0.035)^c	0.0	−0.000 (−0.021 to 0.021)	32.4	0.017 (0.003 to 0.032)^c	0.0	0.008 (−0.012 to 0.029)	42.0
Subgroup	Female	3 (1165)	0.035 (0.006 to 0.064)^c	0.0	0.020 (−0.001 to 0.040)	0.0	0.015 (−0.013 to 0.043)	0.0	0.019 (0.001 to 0.037)^c	0.0	0.023 (−0.003 to 0.050)	0.0
Distal radius
Overall		3 (4003)	0.008 (0.008 to 0.008)^c	0.0	0.003 (0.003 to 0.003)^c	0.0	0.005 (0.005 to 0.005)^c	0.0	0.004 (0.004 to 0.005)^c	0.0	0.006 (0.006 to 0.006)^c	0.0
Middle radius
Overall		3 (1061)	0.007 (−0.004 to 0.018)	0.0	0.006 (−0.002 to 0.014)	0.0	0.001 (−0.010 to 0.011)	0.0	0.007 (−0.001 to 0.014)	0.0	0.003 (−0.007 to 0.013)	0.0
Ultradistal radius
Overall		3 (1061)	0.005 (−0.006 to 0.016)	0.0	0.004 (−0.004 to 0.012)	0.0	0.002 (−0.009 to 0.012)	0.0	0.004 (−0.003 to 0.012)	0.0	0.003 (−0.007 to 0.013)	0.0

^{^a}

All studies recruited European populations at whole body and distal radius; all subjects were women at the total hip, distal radius, middle radius, and ultradistal radius; all studies were classified as high quality at the trochanter, whole body, Ward's triangle, distal radius, middle radius, and ultradistal radius.

^{^b}

Only the difference for CC/CG versus GG was included in one study (Fontova et al., 2002).

^{^c}

Significant results, p-value<0.05.

^{^d}

Significant between-study heterogeneity (p<0.10), random-effects model was used.

^{^e}

Only the difference for CC versus CG/GG was included in one study (Ferrari et al., 2003).