Table 2.

Differentially expressed proteins in sera after RIPC compared with that in sera before RIPC.

Spota	Protein name	Accession numberb	Protein MW (Da)	Protein PIc	Sequence coveraged (%)	Fold changee	Protein scoref
(i)	Immune system process
1	Complement component 4B	IPI00887154	192627.5	6.89	2	↓1.951 h	158
2	Complement C1q subcomponent subunit B	IPI00477992	26704.5	8.83	22	↓2.733 h	84
3	Complement C3	IPI00783987	187029.9	6.02	15	↓2.231 h	121
4	C4b-binding protein alpha chain	IPI00021727	66989.4	7.15	9	↓1.511 h	71
5	Ficolin-3	IPI00419744	31657.4	6.36	18	↑1.521 h	107
6	Interalpha-trypsin inhibitor heavy chain H4	IPI00896419	103293	6.51	18	↑2.511 h	97
7	Vitronectin	IPI00298971	54271.2	5.55	4	↓1.521 h	70
(ii)	Lipid metabolic process
8	Apolipoprotein A-I	IPI00021841	30758.9	5.56	25	↓3.851 h	79
9	Apolipoprotein L1	IPI00514475	43946.9	5.6	28	↑1.681 h	88
10	Apolipoprotein J	IPI00291262	52461	5.89	20	↓1.7424 h	219
(iii)	Apoptosis
11	Desmoplakin	IPI00013933	331568.7	6.44	8	↑1.6248 h	67
12	Gelsolin	IPI00026314	85644.2	5.9	16	↑2.211 h	131
(iv)	Blood coagulation
13	Antithrombin-III	IPI00032179	52657.8	6.11	23	↓2.011 h	180
14	Heparin cofactor 2	IPI00879573	57034.2	6.41	17	↑2.321 h	64

^aSpot number refers to Figure 1.

^bAccession number from IPI (International Protein Index) database of matched proteins.

^cPI refers to isoelectric point.

^dPercent of number of observed amino acids in sequence length (%).

^e“↓” means downregulation, and “↑” means upregulation. Superscripts such as “1h” represented the time point when the fold change reached maximum. The fold change in the table was the maximum change among the different time points.

^fCombined scores of all observed mass spectra matched to amino acid sequences used for protein identification.