Table 1.

Well-documented CSF markers in dementias [69, 103, 142]

Test	Cutoff (pg/ml)	Specificity / Sensitivity	MCI →AD
		clin. AD versus controls /versus non-AD dementias
tTau	300–500	0.85–1.0 / 0.40–0.89	SP 0.70
	250	AD versus LBD SP 0.76
	2130	CJD versus AD 1.0 / 0.93
Aβ-42	375–500	0.47–1.0 / 0.78–1.0 // 0.6–0.9 / 0.85	1.0 / 0.83
Aβ-40		Not relevant (no differences)
Aβ ratio (40 / 42)		0.82 / 0.58
Tau /Aβ ratio	0.5	0.82 / 0.58	AD versus LBD 0.84 / 0.79
Tau × Aβ ratio		0.88 / 0.69
tTau + Aβ-42		0.81–1.0 / 0.63–0.89; 0.75–0.93 / 0.71	0.90 / 0.83
		AD versus LBD SP 0.67;
		AD versus VaD 0.58–0.83 / 0.90
		AD versus FTD SP 0.58
pTau		0.80–0.85 / 0.90–0.94	MCI →AD 1.0 / 0.65
		AD versus FTD 0.92 / 0.90
pTau + Aβ-42		0.97 / 0.89	0.80 / 0.73–0.89
		AD versus FTD 0.93 / 0.72

Formulas:

Specificity (SP) = definitely negative / (definitely negative + wrong positive)

Sensitivity (ST) = definitely positive / (definitely positive + wrong negative)