Table 1.
Effect of G-CSF and inhibitors on cardiac function at 4 weeks after surgery
| n | Sham + Saline 10 | Sham + G-CSF 10 | MI + Saline 10 | MI + G-CSF 11 | MI + G-CSF + Parthenolide 6 | MI + G-CSF + Wortmannin 7 |
|---|---|---|---|---|---|---|
| LVDd, mm | 3.69 ± 0.03 | 3.70 ± 0.03 | 5.70 ± 0.01* | 5.10 ± 0.01*# | 6.37 ± 0.20*+ | 4.78 ± 0.15*# |
| FS, % | 33.8 ± 0.6 | 35.0 ± 0.7 | 11.4 ± 1.2* | 19.3 ± 1.5*# | 13.9 ± 0.6*+ | 22.9 ± 0.7*# |
| HR, bpm | 538 ± 45 | 542 ± 20 | 558 ± 10* | 600 ± 16*# | 516 ± 12*+ | 535 ± 26*# |
| LVSP, mmHg | 108 ± 2.8 | 110 ± 2.4 | 55 ± 2.4* | 65 ± 2.7*# | 57 ± 2.0*+ | 71 ± 2.1*# |
| LVEDP, mmHg | 0.7 ± 0.2 | 0.5 ± 0.1 | 10.0 ± 0.9* | 5.2 ± 0.6*# | 9.4 ± 1.3*+ | 4.4 ± 0.7*# |
| +dP/dt, mmHg/s | 8795 ± 459 | 9126 ± 584 | 2666 ± 345* | 4176 ± 403*# | 2894 ± 244*+ | 4881 ± 159*# |
| −dP/dt, mmHg/s | −8994 ± 466 | −9266 ± 509 | −2528 ± 264* | −3681 ± 319*# | −2449 ± 215*+ | −4435 ± 287*# |
MI, myocardial infarction; LVDd, left ventricular end-diastolic diameter; FS, fractional shortening; LVSP, left ventricular peak systolic pressure; LVEDP, left ventricular end-diastolic pressure; *P < 0.05 versus saline-treated sham; #P < 0.05 versus saline-treated hearts with MI; +P < 0.05 versus G-CSF-treated hearts with MI.