Table 5.

Selected genetic networks with high scores (>10) in WTIR versus KOIR comparison

Molecules in network	Score	Focus genes	Top functions
Akt, Ap1, BTRC, CAMK2D, CLEC11A, CXCL1, CXCL11 (includes EG:6373), EIF2S1, FCGR1A, FGF1, HIF1A, H0MER1, IL1, IL11, IL1R2, Jnk, MAP3K3, Mapk, Mek, P38 MAPK, PI3K, Pkc(s), PMCH, PP2A, PPP1R1A, PSCD3, PSCDBP, PSMC3IP, PTGFR, RTN4, SIAH1,SLC12A7, ULBP2, Vegf, WNK1	42	22	Cardiovascular system development and function, cell-to-cell signalling and interaction, gene expression
Amino acids, ARHGDIG, ARHGEF11, B3GALT2, CASC3, CD38, CDC6, CDC25C, CENPJ, COG2, COG7, CPE, GYS1 (includes EG:2997), HNRPA1, HNRPC, hydrogen peroxide, INS1, MAGOH, MCF2L, MPO, NXF1, PHGDH, PLK3, P0LR2A, P0U2F1, PPM1D, PTPRO, RBM8A, RCN1, RHOA, RHPN2, SYTL4, THOC4, TNF, TNFAIP8	27	15	Carbohydrate metabolism, lipid metabolism, molecular transport
ARFGEF1, ARHGDIG, ARHGEF11, β-estradiol, CAD, CD200, CD200R1, CDH4, CLCN3, CRSP2, CUBN, DOK1, EGF, FOXA2, HCRTR2, IGHMBP2, LDLR, Mmp, MMP2, MY09B, PDGFB, PKIB, PLCE1, PSCD3, RHOA, SCARB1, SERPINA1, SETD7, SGK3, SLC9A3R1, TAF7, TBN, TBP, TRFP, USP6NL	25	15	Lipid metabolism, molecular transport, small molecule biochemistry
AK3L1, ATR, CCNA1, CCNA2, CD9, CDC6, CDC25A, CDC25B, CDC25C, CDK6, CHEK2, COL18A1, CPOX, E2F6, E2F1 (includes EG:1869), EGLN1, ERCC3, FBXW11, FLU, GTF2H1, HIF1A, MGA (includes EG:23269), MXD4, MYCT1, NDNL2, NRN1, PRKDC, RBX1, SREBF1, STARD4, TGFB1, TP53, USP7, ZFP161, ZNF22	24	14	Cell cycle, gene expression, DNA replication, recombination and repair
AHR, CLEC11A, CYP2B6, DLG2, DLG3, DLGAP1, DNAJC11, FLNB, FOS, GRASP, GRIN1, heparin, HLTF, IL10, MAGI2, MLLT10, MMP2, MPG, NRP1, PCNX, POLR3A, POLR3F, PPARBP, RB1, RBBP9, retinoic acid, SE -MA3D, SHANK2, SMARCA4, S MAR -CB1, SPTBN1, ST6GALNAC4, TCOF1 (includes EG:6949), YY1, ZFAND5	25	15	Organismal development, gene expression, cancer