Table 6.
Selected genetic networks with High scores (>10) in WTPCIR versus KOPCIR comparison
| Molecules in network | Score | Focus genes | Top functions |
|---|---|---|---|
| ADRBK2, BTRC, CCND2, Creb, DRD1, DYRK2, FCGR2B, FLU, GRIP1, HDC, HIF1A, HIF1AN, HLTF, IL11, Jnk, Mapk, MAPT, NCAM1, NPR3, P38 MAPK, Pdgf, PI3K, Pkc(s), PMCH, PRKG1 (includes EG:5592), RUNX -1, Scf, SLC6A3, SP1, TCF12, Tgf beta, TLR4, Vegf, WNT5A,YES1 | 45 | 24 | Cell-to-cell signalling and interaction, cellular growth and proliferation, cellular development |
| Akt, Ap1, APAF1, CXCL11 (includes EG: 6373), DUSP6, FLI1, FST, Hsp90, Jnk, LDL R, Mapk, NR3C1, P38 MAPK, p70 S6k, Pdgf, PDGFC, PEPCK, PI3K, PIK3C3, PIK3CA, PMCH, PP1/PP2A, PPARGC1A, PPM1L, PPP1R11, PSCDBP, PSMC3IP, RASSF1, Scf, SULF1, TFDP1,Tgf-β, TLR3, TRAF3, VCAM1 | 40 | 22 | Endocrine system development and function, lipid metabolism, molecular transport |
| AM0TL1, β-estradiol, BMX, CD44, CDH11, CEBPG, CXCR7, DAG1, EIF2S3, FIGF, GBP2 (includes EG:14469), GFAP, GPC1, GPRC5A, IFNGR2, IL6, IL15, KDR, L-carnitine, LARGE, MVP, NFKBIZ, NRP1, PLP1, PPP5C, PRKDC, PSEN1, psychosine, RAPGEF5, SDC3, SNX10, ST6GAL1, TNF, TNFAIP8, VEGFC | 26 | 16 | Cellular movement, cardiovascular system development and function, organismal development |
| ARCN1, ATM/ATR, BCL10, BRCA1, BRCC3, BRE, CASP9, CCND2, CHEK2, DAG1, ELK1, EPOR, GAST, HDC, HMGN3, IL3, IL1RL1, KLF7, MDC1, PCDH7, PLK3, PTX3, RAD50, RANBP9, RAPGEF5, RELB, ROB01, SRPK2, TNF, TNFAIP3, TNFAIP6, TNFAIP8, TROVE2, USP11, ZFAND5 | 26 | 16 | Cell death, cell cycle, cancer |
| ATR, Caspase, CDH1, CDT1, CEP55, CUL4B, ERCC1, ETS1, FAM3C, Groucho, HAS2, HNRPA2B1, HRAS, HRASLS, IGFBP3,IGSF4(includesEG:23705), JMJD1C, MATN4, MLLT4, NOTCH1, P8, PAXIP1, PVR, PVRL- 3, RUNX1, SOAT1, SON, TIMP3, TLE1, TP53, TP53BP1, TRIM44, UPP1, UTY, Zn2+ | 24 | 15 | Cell death, connective tissue disorders, cancer |
| ATXN1, AURKA, CDC7, CEP55, CHGN, DBF4, DDX6 (includes EG:1656), EP400, GAPDH (includes EG:2597), GPS2, GSR, JMJD1C, KIAA1267, MAP4, MARK4 (includesEG:57787), MCM2, MCM4, MCM6, MCM7, MED6, MGA (includes EG:23269), MLL, PPP1R15A (includes EG:23645), PRNP, PVRL3, SFRS10, TBL1X, TFDP1, THPO, TNFRSF10A (includes EG:8797), TP53, TRIM44, TXNRD1, USP7,WDR5 | 24 | 15 | DNA Replication, Recombination and repair, cell cycle, cell death |