Table 7.
Gene ontology analysis of the genes affected in WTIR versus KOIR comparison
| Relevant functions | P-value | No. of molecules |
|---|---|---|
| Organismal injury and abnormalities | 8.39E-4 – 4.76E-2 10 | 10 |
| Cardiovascular system development and function | 8.39E-4 – 4.47E-2 9 | 9 |
| Free radical scavenging | 7.59E-3 – 7.59E-3 1 | 1 |
| Cellular growth and proliferation | 7.59E-3 – 4.95E-2 23 | 23 |
| Haematological system development and function | 7.59E-3 – 4.95E-2 14 | 14 |
| Molecular transport | 7.59E-3 – 4.57E-2 12 | 12 |
| Cellular development | 7.59E-3 – 4.47E-2 7 | 7 |
| Connective tissue development and function | 7.59E-3 – 4.47E-2 6 | 6 |
| Drug metabolism | 7.59E-3 – 4.47E-2 6 | 6 |
| Cellular movement | 7.59E-3 – 4.47E-2 19 | 19 |
| Cell cycle | 7.59E-3 – 3.74E-2 7 | 7 |
| Nucleic acid metabolism | 7.59E-3 – 3.74E-2 2 | 2 |
| DNA replication, recombination and repair | 7.59E-3 – 3.00E-2 4 | 4 |
| Metabolic disease | 7.59E-3 – 3.00E-2 4 | 4 |
| Cardiovascular disease | 6.18E-3 – 4.47E-2 8 | 8 |
| Tissue development | 5.89E-4 – 4.90E-2 22 | 22 |
| Skeletal and muscular system development and function | 5.89E-4 – 4.47E-2 10 | 10 |
| Cell death | 4.89E-3 – 4.76E-2 11 | 11 |
| Embryonic development | 4.89E-3 – 4.47E-2 4 | 4 |
| Cell-to-cell signalling and interaction | 4.61E-3 – 4.47E-2 19 | 19 |
| Cellular assembly and organization | 3.58E-3 – 4.47E-2 21 | 21 |
| Skeletal and muscular disorders | 3.58E-3 – 4.47E-2 11 | 11 |
| Nutritional disease | 3.00E-2 – 3.74E-2 1 | 1 |
| Protein trafficking | 2.26E-2 – 3.00E-2 2 | 2 |
| Organismal development | 1.58E-3 – 4.57E-2 15 | 15 |
| Vitamin and mineral metabolism | 1.51E-2 – 4.57E-2 4 | 4 |
| Cell signalling | 1.51E-2 – 4.57E-2 19 | 19 |
| Post-translational modification | 1.51E-2 – 3.74E-2 4 | 4 |
| Cellular function and maintenance | 1.51E-2 – 2.26E-2 5 | 5 |
| Gene expression | 1.21E-3 – 4.91E-2 27 | 27 |
| Lipid metabolism | 1.17E-3 – 4.47E-2 6 | 6 |