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. 2008 Mar 4;12(4):1347–1359. doi: 10.1111/j.1582-4934.2008.00299.x

Fig. 2.

Fig. 2

(A-C) Cell morphology at PDL 31, 121 and 224 of hMSC clone (SCP-1) ectopically expressing telomerase. (D, E) Senescence-associated β-galactosidase assay. Untransduced hMSCs show pronounced β-galactosidase activity at PDL 24. In contrast, hTERT-transduced hMSCs had no β-galactosidase activity even at higher passages. (F) Growth curve of untransduced hMSC (hMSCs), heterogeneous (hTERT-hMSCs) and single-cell-picked hMSC clones (SCP-1, -9, -11–12). (G) BrdU assay of heterogeneous hTERT-hMSCs and SCP-1 showed a significantly higher proliferation of SCP-1 (P= 0.00014 hTERT young [PDL 31]versus SCP-1 young passage [PDL 31]).