Table 2.

Biodistribution of ^99mTc-DTPA-glipizide in normal healthy F-344 rats

	30 min	60 min	180 min
Blood	2.08 ± 0.11*	1.66 ± 0.04*	1.25 ± 0.04*
Heart	0.49 ± 0.04*	0.33 ± 0.02*	0.29 ± 0.03*
Lung	0.84 ± 0.01*	0.72 ± 0.05*	0.52 ± 0.02*
Thyroid	0.70 ± 0.14	0.54 ± 0.02*	0.41 ± 0.01*
Pancreas	0.25 ± 0.03	0.21 ± 0.00*	0.15 ± 0.01*
Liver	1.10 ± 0.04	1.01 ± 0.05*	0.78 ± 0.00*
Spleen	0.72 ± 0.03	0.74 ± 0.04	0.60 ± 0.02*
Kidney	5.78 ± 0.30	7.52 ± 0.33*	7.38 ± 0.29
Stomach	0.25 ± 0.01	0.20 ± 0.00	0.16 ± 0.01
Intestine	0.59 ± 0.11	1.66 ± 0.04	0.25± 0.01*
Brain	0.06 ± 0.01	0.04 ± 0.01*	0.04 ± 0.00*
Muscle	0.10 ± 0.00	0.08 ± 0.00*	0.06 ± 0.00*
Bone	0.20 ± 0.03	0.11 ± 0.01	0.14 ± 0.02*
P/blood	0.12 ± 0.01	0.13 ± 0.01*	0.12 ± 0.00*
P/muscle	2.54 ± 0.26	2.76 ± 0.07*	2.50 ± 0.18

Values are % of injected dose per gram of tissue weight and represent the mean ± standard errors of the mean of data from 3 animals per time interval

^*p <0.05 vs. ^99mTc-DTPA