Table 3.

Risk of stillbirth and various indicators of neonatal outcomes (cardio-pulmonary resuscitation or respirator care, monitoring or neonatal intensive unit care, and birth asphyxia) among offspring of women with a history of cancer as compared with offspring of female siblings using data from the Medical Birth Registry (1987–2007)

	Offspring of female
Outcome	Cancer survivors	Siblings	Crude OR	95% CI	Adjusted OR‡	95% CI	Adjusted ORa	95% CI
	Liveborn n = 3,513 (%)	Liveborn n = 16,958 (%)
Stillbirth	12 (0.3)	50 (0.29)	1.15	0.61–2.19	1.12	0.56–2.26	0.77	0.33–1.78
CPR or respirator care*	60 (1.7)	182 (1.1)	1.63	1.20–2.23	1.42	1.04–1.96	1.12	0.76–1.65
Monitoring or NICU care*	450 (12.8)	1311 (7.8)	1.90	1.65–2.19	1.56	1.35–1.80	1.44	1.25–1.66
Birth asphyxia*	79 (2.3)	322 (1.9)	1.21	0.92–1.59	0.93	0.70–1.22	0.92	0.70–1.22

Abbreviations: CI, confidence interval; CPR cardio-pulmonary resuscitation; NICU, neonatal intensive care unit; OR, odds ratio.

^‡Odds ratios are derived from random effects logistic regression models, adjusted for maternal age, delivery year, infant sex, maternal smoking, maternal hypertension, placental problems, maternal infections, birth order, maternal diabetes or impaired glucose tolerance, and pre-eclampsia.

^aOdds ratios are derived from random effects logistic regression models, adjusted for maternal age, delivery year, infant sex, maternal smoking, maternal hypertension, placental problems, maternal infections, gestational age, birth order, maternal diabetes or impaired glucose tolerance, pre-eclampsia and gestational age.

^*The denominator for neonatal morbidity outcomes included only live-born offspring and was 3501 for patients and 16908 for siblings.