Table 1.
14-3-3 isoform | Isoform-specific histology | Interacting partner and disease involvement |
---|---|---|
β | Tangles in AD LBHI in ALS GCI in MSA |
LRRK2; PD NFL mRNA; ALS Tau, SPRK2, FOXO1; AD Ataxin-1; SCA1 ASK1; Epilepsy GFAP; MS |
| ||
γ | Tangles in AD Lewy bodies in PD LBH in ALS GCI in MSA |
LRRK2; PD NFL mRNA; ALS |
| ||
ε | Tangles in AD Lewy bodies in PD GCI in MSA |
LRRK2; PD Cdc25, SPRK2; AD Ataxin-1; SCA1 GFAP; MS |
| ||
ζ | Tangles in AD Lewy bodies in PD Amyloid plaque in CJD GCI in MSA |
Tyrosine hydroxylase, LRRK2; PD NFL mRNA; ALS GSK3β, tau; AD Ataxin-1; SCA1 Huntingtin; HD Bad, Bax; Ischemia GFAP; MS |
| ||
η | Parkin, LRRK2; PD NFL mRNA; ALS Tau; AD |
|
| ||
σ | Tangles in AD | SPRK2; AD |
| ||
θ/τ | Lewy bodies in PD GCI in MSA |
Bad, Bax, LRRK2; PD NFL mRNA; ALS |