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. 2014 Jan 1;141(1):187–198. doi: 10.1242/dev.092536

Fig. 7.

Fig. 7.

Notch functions upstream of BMP signaling. (A-F′) Overexpression of NICD induced widespread expression of Dll4, pSmad, Msx1/2 and Gata3 but caused marked downregulation of Ascl1 and Chx10 expression on the electroporated side. (G-L′) Co-electroporation of chordin with NICD failed to induce ectopic pSmad and Msx1/2 expression, diminished Gata3 induction, but still led to induction of Dll4 expression and inhibition of Ascl1 and Chx10 expression. Transverse sections through chick spinal cords at stages 22-24 are shown in all panels. Right side inserts show GFP expression to indicate the extent of transfection. The dashed line in C indicates the ventral limit of endogenous Msx expression. Scale bar: 10 μm.