Table 2.
BACEs, BACE-like sequences and homologs used for phylogenetic analysis.
| Short sequence name | Species name | Common name | NCBI Tax ID | UniProt ID | Protein length |
|---|---|---|---|---|---|
| Ur-BACE | |||||
| Mono_ovat_A | Monosiga ovata | Choanoflagellate | 81526 | 459 | |
| Mono_ovat_B | Monosiga ovata | Choanoflagellate | 81526 | 541 | |
| Tric_adhe_A | Trichoplax adhaerens | Tricoplax | 10228 | 545 | |
| Tric_adhe_B | Trichoplax adhaerens | Tricoplax | 10228 | B3RU95 | 505 |
| Tric_adhe_C | Trichoplax adhaerens | Tricoplax | 10228 | B3RU94 | 428 |
| Nema_vect | Nematostella vectensis | Sea Anemone | 45351 | 479 | |
| Aipt_pall | Aiptasia pallida | Sea Anemone | 12566 | 488 | |
| Hydr_mag | Hydra magnipapillata | Hydra | 6085 | 412 | |
| Clyti_hem | Clytia hemisphaerica | Sponge | 252671 | 474 | |
| Acro_mill | Acropora millepora | Stony Coral | 45264 | 365 | |
| Clon_sine | Clonorchis sinensis | Oriental Liver Fluke | 79923 | 506 | |
| Schi_japo | Schistosoma japonicum | Fluke | 6182 | 488 | |
| Schi_mans | Schistosoma mansoni | Fluke | 6183 | G4VD03 | 507 |
| Plan_schm | Schmidtea mediterranea | Planarium | 79327 | 516 | |
| Capi_tela | Capitella telata | Polychaete annelid | 283909 | 504 | |
| Mere_mere | Meretrix meretrix | Asiatic Hard Clam | 291251 | 362 | |
| Rudi_phil | Ruditapes philippinarum | Manila Clam | 129788 | 186 | |
| Vill_lien | Villosa lienosa | Freshwater Mussel | 326719 | 326 | |
| Cras_giga | Crassostrea gigas | Pacific oyster | 29159 | 520 | |
| Lott_giga | Lottia gigantea | Owl limpet | 225164 | 495 | |
| Ilya_obso | Ilyanassa obsoleta | Eastern mudsnail | 34582 | 250 | |
| Lymn_stagn | Lymnaea stagnalis | Pond Snail | 6523 | 544 | |
| Eupr_scolo | Euprymna scolopes | Squid | 6613 | 215 | |
| Stron_purp | Strongylocentrotus purpuratus | Sea Urchin | 7668 | 538 | |
| Para_livi | Paracentrotus lividus | Purple Sea Urchin | 7656 | 297 | |
| Sacc_kowa | Saccoglossus kowalevskii | Acorn Worm | 10224 | 268 | |
| Cion_inte | Ciona intestinalis | Sea Squirt | 7719 | 466 | |
| Cion_savi | Ciona savignyi | Sea Squirt | 51511 | 458 | |
| Halo_rore | Halocynthia roretzi | Sea Squirt | 7729 | 463 | |
| Bran_flor | Branchiostoma floridae | Amphioxus | 7739 | C3ZMY0 | 493 |
| Petr_mari | Petromyzon marinus | Lamprey | 7757 | 406 | |
| BACE1 | |||||
| Hum_BACE1 | Homo sapiens | Human | 9606 | P56817 | 501 |
| Mouse_BACE1 | Mus musculus | Mouse | 10090 | P56818 | 501 |
| Rat_BACE1 | Rattus norvegicus | Rat | 10116 | P56819 | 501 |
| Dog_BACE1 | Canis familiaris | Dog | 9615 | 501 | |
| Bov_BACE1 | Bos taurus | Cow | 9913 | Q2HJ40 | 501 |
| Mono_dome_BACE1 | Monodelphis domestica | Opossum | 13616 | 466 | |
| Ailu_melan_BACE1 | Ailuropoda melanoleuca | Panda | 9646 | 501 | |
| Orin_anat_BACE1 | Ornithorhynchus anatinus | Platypus | 9258 | 475 | |
| Gall_Gal_BACE1 | Gallus gallus | Chicken | 9031 | 426 | |
| Taen_gutt_BACE1 | Taeniopygia guttata | Zebra Finch | 59729 | 522 | |
| Xeno_trop_BACE1 | Xenopus tropicalis | Western clawed frog | 8364 | Q0P4T5 | 502 |
| Anol_caro_BACE1 | Anolis carolinensis | Lizard | 28377 | 318 | |
| Pelo_sine_BACE1 | Pelodiscus sinensis | Chinese Soft- Shelled Turtle | 13735 | 484 | |
| Chry_pict_BACE1 | Chrysemys picta bellii | Western painted Turtle | 8478 | 437 | |
| Dani_reri_BACE1 | Danio rerio | Zebrafish | 7955 | 531 | |
| Taki_rubr_BACE1 | Takifugu rubripes | Fugu | 31033 | 443 | |
| Tetr_nigr_BACE1 | Tetraodon nigroviridis | Pufferfish | 99883 | Q4RYS5 | 448 |
| Gast_acul_BACE1 | Gasterosteus aculeatus | Sticklback | 69293 | 490 | |
| Oryz_lati_BACE1 | Oryzias latipes | Medaka | 8090 | 442 | |
| Lat_chal_BACE1 | Latimeria chalumnae | Coelocanth | 7897 | 488 | |
| Gadu_morh_BACE1 | Gadus morhua | Cod | 8049 | 481 | |
| Oreo_nilo_BACE1 | Oreochromis niloticus | Nile Tilapia | 8128 | 488 | |
| Salm_salm_BACE1 | Salmo salar | Atlantic Salmon | 8030 | 348 | |
| Leuc_erin_BACE1 | Leucoraja erinacea | Little Skate | 7782 | 203 | |
| Squa_acan_BACE1 | Squalus acanthias | Spiney Dogfish | 7797 | 202 | |
| BACE2 | |||||
| Hum_BACE2 | Homo sapiens | Human | 9606 | Q9Y5Z0 | 518 |
| Mouse_BACE2 | Mus musculus | Mouse | 10090 | Q9JL18 | 515 |
| Rat_BACE2 | Rattus norvegicus | Rat | 10116 | Q6IE75 | 514 |
| Dog_BACE2 | Canis familiaris | Dog | 9615 | 422 | |
| Cow_BACE2 | Bos taurus | Cow | 9913 | 473 | |
| Mono_dome_BACE2 | Monodelphis domestica | Opossum | 13616 | 531 | |
| Orni_anat_BACE2 | Ornithorhynchus anatinus | Platypus | 9258 | 423 | |
| Ailu_melan_BACE2 | Ailuropoda melanoleuca | Panda | 9646 | 426 | |
| Xeno_laev_BACE2_A | Xenopus laevis | African Clawed Frog | 8355 | Q7T0Y2 | 500 |
| Xeno_laev_BACE2_B | Xenopus laevis | African Clawed Frog | 8355 | Q6PB20 | 499 |
| Xeno_trop_BACE2 | Xenopus tropicalis | Western Clawed Frog | 8364 | B4F734 | 499 |
| Anol_carol_BACE2 | Anolis carolinensis | Lizard | 28377 | 417 | |
| Amb_tigr_BACE2 | Ambystoma tigrinum tigrinum | Eastern tiger salamander | 43116 | 337 | |
| Pelo_sine_BACE2 | Pelodiscus sinensis | Chinese Soft-Shelled Turtle | 13735 | 415 | |
| Chry_pict_BACE2 | Chrysemys picta bellii | Western painted Turtle | 8478 | 438 | |
| Gall_gall_BACE2 | Gallus gallus | Chicken | 9031 | 416 | |
| Taen_gutt_BACE2 | Taeniopygia guttata | Zebra Finch | 59729 | 441 | |
| Dani_reri_BACE2 | Brachydanio rerio | Zebrafish | 7955 | 503 | |
| Taki_rubr_BACE2 | Takifugu rubripes | Fugu | 31033 | 470 | |
| Tetr_nigr_BACE2 | Tetraodon nigroviridis | Spotted Green Pufferfish | 99883 | 472 | |
| Oryz_lati_BACE2 | Oryzias latipes | Medaka | 8090 | 437 | |
| Gast_acul_BACE2 | Gasterosteus aculeatus | Sticklback | 69293 | 508 | |
| Gadu_morh_BACE2 | Gadus morhua | Cod | 8049 | 497 | |
| Lati_chum_BACE2 | Latimeria chalumnae | Coelocanth | 7897 | 382 | |
| Oreo_nilo_BACE2 | Oreochromis niloticus | Nile Tilapia | 8128 | 509 | |
| Onco_myki_BACE2 | Oncorhynchus mykiss (+nerka) | Rainbow Trout | 8022 | 406 | |
| Salm_sala_BACE2 | Salmo salar | Atlantic Salmon | 8030 | 230 | |
| BASAL CATHEPSINS | |||||
| Plan_schm_cath01 | Schmidtea mediterranea | Planarium | 79327 | 389 | |
| Tric_adhe_cath01 | Trichoplax adhaerens | Tricoplax | 10228 | B3RK44 | 383 |
| Bran_flor_cath01 | Branchiostoma floridae | Amphioxus | 7739 | C3YBT8 | 423 |
| Mono_ovat_cath01 | Monosiga ovata | Choanoflagellate | 81526 | 381 | |
| Nema_vect_cath01 | Nematostella vectensis | Sea Anemone | 45351 | 370 | |
| Stro_purp_cat01 | Strongylocentrotus purpuratus | Sea Urchin | 7668 | 313 | |
| Cion_inte_cath01 | Ciona intestinalis | Sea Squirt | 7719 | 385 | |
| Cion_sauv_cath01 | Ciona savignyi | Sea Squirt | 51511 | H2ZA35 | 370 |